| 100% | THEPRU | 6 | 52-story Boston skyscraper, familiarly |
| 68% | PRU | 3 | With "the," Boston skyscraper, familiarly |
| 63% | THEPRU | 6 | Boston skyscraper named for an insurance company, familiarly |
| 55% | PRU | 3 | The ___ (Boston skyscraper, familiarly) |
| 48% | PRU | 3 | Boston skyscraper, with "the" |
| 48% | PRU | 3 | Boston skyscraper, with “the” |
| 46% | PRU | 3 | Boston skyscraper, informally, with "the" |
| 46% | PRU | 3 | Boston skyscraper nickname, with "the" |
| 45% | PRU | 3 | Boston skyscraper's nickname, with "The" |
| 44% | SOX | 3 | Boston team, familiarly |
| 44% | UMASS | 5 | Boston campus, familiarly |
| 44% | FLOORS | 6 | Skyscraper's stories |
| 43% | PRU | 3 | The ___ (nickname for a Boston skyscraper) |
| 42% | INSTA | 5 | App with Stories, familiarly |
| 40% | MASSGENERAL | 11 | Boston's flagship medical center, familiarly |
| 40% | THET | 4 | Boston bus-and-subway system, familiarly |
| 39% | AMES | 4 | ___ Building, first skyscraper in Boston |
| 39% | AMES | 4 | ___ Building, Boston's first skyscraper |
| 36% | PRU | 3 | Boston-skyscraper nickname |
| 36% | SAMADAMS | 8 | Official beer of the Boston Red Sox, familiarly |
| 36% | INSTA | 5 | Social media app with Reels and Stories, familiarly |
| 34% | INSTA | 5 | App with Stories and Reels, familiarly |
| 34% | INSTA | 5 | Site with Stories and Reels, familiarly |
| 34% | PRU | 3 | The ___ (Boston skyscraper) |
| 34% | PRU | 3 | "The ___" (Boston skyscraper) |
| 34% | NERO | 4 | Role played by 52-Across in "The Story of Mankind" |
| 29% | SPOTLIGHT | 9 | Best Picture Oscar winner starring 52-Across as Bernard Cardinal Law, Archbishop of Boston |
| 29% | PRU | 3 | The ___ (Boston skyscraper with the Skywalk Observatory, informally) |
| 28% | TRIDELT | 7 | Member of a sorority founded at Boston University, familiarly |
| 26% | HIGHRISE | 8 | Skyscraper |