| 100% | GEMS | 4 | A girl's best friends, maybe |
| 75% | STYNE | 5 | "Diamonds Are a Girl's Best Friend" composer |
| 75% | ARE | 3 | "Diamonds ___ a girl's best friend" |
| 72% | DIAMONDS | 8 | Precious gems that are a girl's best friend? |
| 60% | ALPO | 4 | Best friend's dinner, maybe |
| 59% | NEEDLE | 6 | A syringe's best friend |
| 57% | AREA | 4 | "Diamonds ___ Girl's Best Friend" |
| 56% | MAX | 3 | Caroline's best friend on "2 Broke Girls" |
| 56% | DOG | 3 | Man's best friend as per a phrase |
| 56% | THECARS | 7 | "My Best Friend's Girl" group |
| 56% | THECARS | 7 | "My Best Friend's Girl" band |
| 55% | CECE | 4 | Best friend of Jess on Fox's "New Girl" |
| 55% | AREA | 4 | "Diamonds ___ Girl's Best Friend" (2 wds.) |
| 55% | AREA | 4 | "Diamonds ___ Girl's Best Friend": 2 wds. |
| 55% | THECARS | 7 | "My Best Friend's Girl" rock band |
| 54% | FIB | 3 | Spare a friend's feelings, maybe |
| 53% | PACTS | 5 | Agreements between best friends, maybe |
| 49% | FIDO | 4 | Classic name for a man's best friend |
| 49% | LASSIE | 6 | ''A Boy's Best Friend'' of kid lit |
| 49% | KOOMSON | 7 | Dorothy —, author of novels My Best Friend's Girl and The Ice Cream Girls |
| 49% | MANS | 4 | ___ best friend (term for a dog) |
| 49% | LASS | 4 | Girl in a bonnet, maybe |
| 48% | ANNEFRANK | 9 | A girl known best for her courageous diary |
| 48% | CLOSETO | 7 | A good friend of |
| 47% | PATRICK | 7 | 16-Across' best friend, a pink starfish |
| 46% | HEIDI | 5 | Literary heroine whose best friend is a goatherd |
| 46% | GABBY | 5 | Good name for a talkative girl? |
| 46% | TENACRE | 7 | Like a good-sized estate, maybe |
| 45% | HABIT | 5 | A regular tendency, maybe good or bad |
| 45% | ANEW | 4 | In a better way, maybe |