| 100% | HYPERDRIVE | 10 | A science fiction sitcom in which Nick Frost starred as Space Commander Michael Henderson |
| 33% | GRAVITY | 7 | 2013 science fiction film starring Sandra Bullock as an astronaut who is stranded in space |
| 29% | JONATHAN | 8 | Science fiction film starring Ansel Elgort which was also known as "Duplicate" |
| 29% | LOOKAROUNDYOU | 13 | A comedy series in which Nick Frost portrayed Caveman/Hot Jon: 3 wds. |
| 28% | STRANGER | 8 | "___ Things," Netflix science fiction show which stars Winona Ryder as Joyce Byers |
| 28% | APBIO | 5 | Sitcom starring Glenn Howerton as a high-school science teacher |
| 28% | CHELSEAGRAMMAR | 14 | Star of a sitcom in which the First Daughter learns syntax? |
| 27% | TRANSFORMERS | 12 | Science fiction movie directed by Michael Bay about a race of robots named "Autobots" starring Megan Fox |
| 27% | APBIO | 5 | Sitcom that starred Glenn Howerton as a high school science teacher: 2 wds. |
| 27% | FLUBBER | 7 | Science fiction comedy film which was a remake of "The Absent-Minded Professor" starring Robin Williams |
| 27% | WATERWORLD | 10 | 1995 science fiction film starring Kevin Costner as a mutant with gills on a postapocalyptic Earth |
| 27% | RAYDONOVAN | 10 | A crime drama in which Liev Schreiber stars as the titular character: 2 wds. |
| 27% | GUY | 3 | "Family ___," animated sitcom in which Neil deGrasse Tyson guest-starred as himself |
| 26% | SYNDROME | 8 | Science fiction survival horror video game, released in 2016 be Camel 101, that takes place inside a drifting space ship |
| 26% | INTERSTELLAR | 12 | 2014 science fiction film starring Matthew McConaughey which follows a group of astronauts who travel through a wormhole |
| 26% | DULLEA | 6 | Keir —, US actor who starred as Dr Dave Bowman in 1968 sci-fi film 2001: A Space Odyssey |
| 26% | INTERSTELLAR | 12 | Christopher Nolan science fiction film starring Matthew McConaughey and 44-Across as astronauts who travel through a wormhole |
| 26% | HOWIMET | 7 | "___ Your Mother," a sitcom which starred Neil Patrick Harris as Barney Stinson: 3 wds |
| 26% | THEORY | 6 | "The Big Bang ___," television sitcom in which Neil deGrasse Tyson guest-starred as himself |
| 26% | HOT | 3 | "___ in Cleveland," sitcom in which David Spade guest starred as Christopher |
| 26% | SUDDENLYSUSAN | 13 | 1996-2000 sitcom starring 15-Across as a magazine writer in San Francisco: 2 wds. |
| 26% | BLADERUNNER | 11 | 1982 science fiction film set in a dystopian future Los Angeles and about synthetic humans known as replicants: 2 wds. |
| 25% | AIRFORCEONE | 11 | 1997 film in which Harrison Ford stars as a president whose plane is hijacked by terrorists: 3 wds. |
| 25% | ALDA | 4 | Star as a sitcom surgeon |
| 25% | THEOFFICE | 9 | A comedy which starred Steve Carell as Michael Scott, in which 17-Across played his rival, Charles Miner: 2 wds. |
| 24% | FACTS | 5 | "The ___ of Life" (classic sitcom recreated on "Live in Front of a Studio Audience" starring Jennifer Aniston as Blair) |
| 24% | STEAMPUNK | 9 | Science fiction subgenre set in a retro future |
| 24% | HORSEMAN | 8 | "BoJack ___," animated television series in which Neil deGrasse Tyson guest-starred as a planetarium narrator |
| 24% | THEBRADYBUNCH | 13 | Classic sitcom in which 18-Across played a housekeeper: 3 wds. |