| 100% | PCT | 3 | Abbr. used often in reporting the results of the 2016 presidential election |
| 46% | DANA | 4 | Author Spiotta who wrote “Wayward,” about a woman who flees her suburban family life in the wake of the 2016 Presidential election (July, 2021) |
| 42% | HRC | 3 | Monogram in the 2016 presidential election |
| 39% | AKA | 3 | Abbr. often used on the list of "FBI Ten Most Wanted Fugitives" |
| 38% | PCBS | 4 | Chemicals used in the manufacture of plastics: Abbr. |
| 37% | WEST | 4 | Last part of the country to report election results |
| 37% | TIMKAINE | 8 | Democratic vice presidential candidate in the 2016 election: 2 wds. |
| 36% | SPAVIN | 6 | Enlargement of the hock of a horse often resulting in lameness |
| 35% | CGI | 3 | Type of effects used in the "Avatar" films: Abbr. |
| 35% | CELSHADING | 10 | Technique often used to make 3D images appear in the style of a comic book |
| 34% | ABEVIGODA | 9 | Actor who was the subject of several mistaken death reports before his actual death in 2016 |
| 34% | KATAKANA | 8 | One of the Japanese collections of syllabic symbols most often used in transcribing foreign words into Japanese |
| 34% | STUBBED | 7 | Like an injured toe, often as a result of wandering to the washroom at three in the morning |
| 33% | VIN | 3 | ___ Scully, retired sportscaster who was honored with the Presidential Medal of Freedom in 2016 |
| 33% | ODE | 3 | Type of poem often used as the first word in the poem's title |
| 33% | HORACEGREELEY | 13 | Loser in the 1872 presidential election |
| 33% | ALFLANDON | 9 | Loser in the 1936 presidential election |
| 33% | GRACE | 5 | ___ Hopper, computer scientist who was honored with the Presidential Medal of Freedom posthumously in 2016 |
| 33% | JORDAN | 6 | Michael ___, former professional basketball player who was awarded the Presidential Medal of Freedom in 2016 |
| 33% | KEMP | 4 | Running mate in the 1996 presidential election |
| 33% | CHADS | 5 | "Hanging" problems in the 2000 presidential election |
| 32% | INST | 4 | Abbr., now used infrequently, meaning "of the current month" in formal communication |
| 32% | MAGNIFICAT | 10 | In Christianity, the hymn of the Virgin Mary used as a canticle |
| 32% | SPATULA | 7 | Used for scraping the side of the bowl in baking |
| 32% | UNIVAC | 6 | Computer used to predict the 1952 presidential election |
| 32% | AYERS | 5 | Bill ___, controversial figure in the 2008 presidential election |
| 32% | NAFTA | 5 | Commerce pact mentioned in the 2016 presidential debates |
| 32% | MELANOMA | 8 | Skin tumor, often the result of sun exposure |
| 32% | DYLAN | 5 | Winner of the 2016 Nobel Prize in Literature |
| 32% | FATAL | 5 | Resulting in the death of someone |