| 100% | GREYSANATOMY | 12 | ABC medical drama since 2005 starring 26-Across and created by 38-Across (2 wds.) |
| 49% | THEGOODDOCTOR | 13 | ABC medical drama starring 15-Across, 26-Across/37-Across, and Freddie Highmore as savant surgical resident Shaun Murphy (3 wds.) |
| 45% | SEALTEAM | 8 | CBS military drama created by Benjamin Cavell and starring David Boreanaz: 2 wds. |
| 43% | SUPERFUNNIGHT | 13 | ABC sitcom created by and starring 18-Across: 3 wds. |
| 42% | GREYSANATOMY | 12 | ABC medical drama starring Ellen Pompeo: 2 wds. |
| 42% | GREYSANATOMY | 12 | ABC medical drama that starred Sara Ramirez as bisexual character Callie Torres: 2 wds. |
| 42% | THERESIDENT | 11 | Medical drama starring 17-Across and 28-Across (2 wds.) |
| 40% | THERESIDENT | 11 | Fox TV medical drama starring 17-Across and 28-Across (2 wds.) |
| 40% | DOCTORODYSSEY | 13 | 2024-2025 medical drama aboard a cruise ship that starred 15-Across and Don Johnson: 2 wds. |
| 40% | GREYSANATOMY | 12 | Ellen Pompeo stars in this ABC medical drama set in a Seattle hospital: 2 wds. |
| 38% | FOURBROTHERS | 12 | 2005 film starring Mark Wahlberg and Tyrese Gibson directed by 30-Across (2 wds.) |
| 38% | MARRIAGESTORY | 13 | 2019 drama starring Scarlett Johansson and Adam Driver with music by 33-Across (2 wds.) |
| 38% | THEPITT | 7 | HBO Max medical drama starring Noah Wyle and set in Pennsylvania: 2 wds. |
| 38% | HELLSKITCHEN | 12 | Cooking competition show created and hosted by 18-Across: 2 wds. |
| 38% | GREYSANATOMY | 12 | ABC's medical drama TV series starring Ellen Pompeo that is set in the fictional Seattle Grace Hospital: 2 wds. |
| 38% | MEREDITHGREY | 12 | ABC TV character with a colorful last name, played by Ellen Pompeo since 2005: 2 wds. |
| 38% | GREYSANATOMY | 12 | Ellen Pompeo medical drama that has been on the air since 2005: 2 wds. |
| 38% | THEGOODDOCTOR | 13 | Medical drama starring 15-Across, 30-Across, and Freddie Highmore (3 wds.) |
| 37% | AMERICANIDOL | 12 | Singing TV show since 2002, created by Simon Fuller and hosted by Ryan Seacrest: 2 wds. |
| 37% | ONETREE | 7 | "___ Hill," American teen drama TV series created by Mark Schwahn starring Chad Michael Murray: 2 wds. |
| 37% | BEFORETRILOGY | 13 | Series of three romantic dramas written/directed by Richard Linklater and starring 18-Across and 44-Across (2 wds.) |
| 37% | THEWAYWEWERE | 12 | 1973 romantic drama nominated for six Oscars starring 15-Across and directed by 49-Across (4 wds.) |
| 37% | PEARLHARBOR | 11 | 2001 American romantic period war drama film directed by Michael Bay and starring Ben Affleck: 2 wds. |
| 36% | MARCUSWELBYMD | 13 | Medical drama starring 18-Across and 40-Across that debuted in September 1969 (3 wds.) |
| 36% | SCHITTSCREEK | 12 | Canadian sitcom created by 26-Across and his son Daniel that won a record seven Emmys in 2020 (2 wds.) |
| 36% | LASTCHRISTMAS | 13 | Holiday romcom starring 18-Across and 38-Across and featuring songs by George Michael and Wham! (2 wds.) |
| 36% | COLDMOUNTAIN | 12 | 2003 Civil War drama starring 30-Across and Jude Law: 2 wds. |
| 36% | GREYSANATOMY | 12 | ABC medical drama set in Seattle: 2 wds. |
| 36% | WESTSIDESTORY | 13 | 2021 musical film starring 18-Across and 38-Across directed by Steven Spielberg (3 wds.) |
| 36% | ALLINTHEFAMILY | 14 | 1970s sitcom starring Carroll O'Connor and Jean Stapleton created by 55-Across (4 wds.) |