| 100% | AMINO | 5 | Acid that is a building block for proteins |
| 48% | LEGO | 4 | Toy building block that a chain of theme parks is based on |
| 46% | TRIPUP | 6 | Be a stumbling block for |
| 45% | MIMOLETTE | 9 | Orange colored cheese from France that was blocked in US for having a very high mite level |
| 45% | URIC | 4 | Acid that is often responsible for gout |
| 43% | JASPER | 6 | Quartz aggregate that is a birthstone for March |
| 43% | EAR | 3 | Hearing organ that is a homophone for 43a |
| 43% | FLU | 3 | Winter sickness that is a homophone for 23a |
| 43% | HARE | 4 | Large rabbit that is a homophone for 12a |
| 43% | YEAR | 4 | Calendar unit that is a homophone for 44d |
| 43% | HAIR | 4 | Shampoo target that is a homophone for 12d |
| 43% | VAST | 4 | Ocean adjective that is a synonym for "enormous" |
| 42% | SITE | 4 | Archaeological digging spot that is a homophone for 36a |
| 42% | SUN | 3 | Solar energy source that is a homophone for 34a |
| 42% | MOW | 3 | Trim the lawn that is a homophone for 27a |
| 42% | SON | 3 | Mama's boy that is a homophone for 34d |
| 42% | TIVOLIGARDENS | 13 | Amusement park that was a model for 75-Down |
| 42% | YEWS | 4 | Certain trees that are a homophone for 48-Across |
| 42% | AMINO | 5 | Protein building block, for short |
| 42% | SAUTDEAU | 8 | Waterfall in Haiti that is a shrine for 2 religions |
| 42% | GRACEFUL | 8 | Word to describe swans that is a synonym for "beautiful" |
| 42% | RAP | 3 | Jay-Z's genre that is a homophone for 42d |
| 42% | MOE | 3 | The Simpson's bartender that is a homophone for 27d |
| 41% | EDYS | 4 | Ice Cream brand that is a competitor for Ben & Jerry's |
| 41% | ERG | 3 | Unit of work that is a fraction of joule, for short |
| 41% | CAR | 3 | Four-wheeler that is a popular transport option for road trips |
| 41% | POISE | 5 | Elegant composure that is a synonym for "beautiful" (rhymes with "noise") |
| 41% | PLEASANT | 8 | Word to describe good weather that is a synonym for "beautiful" |
| 41% | YMCA | 4 | Song that was a hit for a spell in the 1970s? |
| 41% | THUNDERROAD | 11 | "Thoroughfare" song that was a hit for Bruce Springsteen (2 wds.) |