| 100% | AOL | 3 | Acquirer of TechCrunch in 2010 |
| 45% | MEDUSA | 6 | Snake-haired character in 2010’s “Clash of the Titans” |
| 45% | BLACKOPS | 8 | 2010 installment in the Call of Duty series |
| 45% | ACA | 3 | Health legislation of 2010, in brief |
| 45% | LIAM | 4 | Neeson who played Zeus in 2010's "Clash of the Titans" |
| 44% | ACA | 3 | Major health legislation of 2010, in brief |
| 43% | MIA | 3 | Actress Wasikowska of 2010's "Alice in Wonderland" |
| 43% | IVF | 3 | Subj. of the 2010 Nobel Prize in Medicine |
| 43% | MIA | 3 | Wasikowska of "Alice in Wonderland," 2010 |
| 42% | USA | 3 | Team in Group C of the 2010 World Cup |
| 42% | TOYSTORY | 8 | Series of films released in 1995, 1999, 2010, 2019 |
| 42% | SUSANAMARTINEZ | 14 | In 2010, she became the first woman to be elected governor of New Mexico: 2 wds. |
| 42% | NIKKIHALEY | 10 | In 2010, she became the first woman to be elected governor of South Carolina: 2 wds. |
| 42% | DEYN | 4 | Agyness —, model-actress who played Aphrodite in 2010 action film Clash of the Titans |
| 41% | PURE | 4 | 2010 Swedish drama film in which Alicia Vikander played the role of Katarina |
| 40% | THEROMANTICS | 12 | 2010 Katie Holmes movie in which she played a maid of honor: 2 wds. |
| 39% | THEUGLYTRUTH | 12 | 2010 book that was #5 in the "Diary of a Wimpy Kid" series: 3 wds. |
| 39% | DRE | 3 | ___ Parker (Jaden Smith’s role in the 2010 remake of “The Karate Kid”) |
| 38% | BUYER | 5 | Acquirer of goods |
| 38% | GENESIS | 7 | 2010 Rock and Roll Hall of Fame inductees with six top-10 hits in the 1980s |
| 38% | PTXXX | 5 | Chrysler model discontinued in 2010 |
| 38% | CONAN | 5 | TBS show starting in 2010 |
| 38% | HUMMER | 6 | Gas guzzler discontinued in 2010 |
| 38% | IPAD | 4 | Tablet first released in 2010 |
| 38% | IPAD | 4 | Apple device introduced in 2010 |
| 38% | NEXUSONE | 8 | Google phone released in 2010 |
| 38% | IPAD | 4 | Popular tablet introduced in 2010 |
| 38% | GOFUNDME | 8 | Kickstarter rival founded in 2010 |
| 38% | IPAD | 4 | Apple product introduced in 2010 |
| 38% | OHS | 3 | 17 of them are sung before "my gosh" in a 2010 #1 Usher hit |