| 100% | BRADPITT | 8 | Actor from "Mr. & Mrs. Smith," who made a guest appearance on then-spouse Jennifer Aniston's "Friends": 2 wds. |
| 55% | HELENHUNT | 9 | "As Good as It Gets" actress, who made a guest appearance on then-spouse Hank Azaria's "The Simpson": 2 wds. |
| 48% | MILAKUNIS | 9 | "Friends With Benefits" actress, who made a guest appearance on boyfriend Ashton Kutcher's "Two And A Half Men": 2 wds. |
| 44% | ADAMWEST | 8 | Batman actor from the 1960s who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 38% | EMMA | 4 | ___ Thompson, "Love Actually" actress who made a guest appearance on "Cheers" as a children's entertainer |
| 38% | LISA | 4 | ___ Kudrow, "Friends" actress who made a guest appearance on "Cheers" as Emily |
| 37% | ELMO | 4 | Red Muppet who made a guest appearance on "The West Wing" |
| 36% | WADE | 4 | ___ Boggs, baseball player who made a guest appearance on "Cheers" as himself |
| 36% | RACHELGREEN | 11 | Jennifer Aniston's "colorful" TV character who maintains they were not, in fact, on a break (2 wds.) |
| 35% | PERI | 4 | ___ Gilpin, "Frasier" actress who made a guest appearance on "Cheers" as a journalist named Holly |
| 34% | DIANANYAD | 9 | Long-distance swimmer who made history on 9/2/2013 by swimming from 33-Across without a shark cage: 2 wds. |
| 33% | JEFFGOLDBLUM | 12 | Actor famous for "Jurassic Park" who appeared as a guest star on "Friends": 2 wds. |
| 33% | WIL | 3 | Actor Wheaton who made several guest appearances on "The Big Bang Theory" |
| 33% | JACKIECHAN | 10 | Actor from Hong Kong who worked in Bruce Lee's movies before becoming a star: 2 wds. |
| 32% | MEG | 3 | Actress Ryan who made a 2015 guest appearance on "Billy on the Street" |
| 32% | PETER | 5 | ___ Benchley, "Jaws" author who made a guest appearance in the book's film adaptation |
| 32% | MEYER | 5 | Stephenie ___, "Twilight" author who made a guest appearance in the book's film adaptation |
| 32% | BON | 3 | ___ Iver (band that makes a guest appearance on Taylor Swift's new album "Evermore") |
| 32% | RACHELGREEN | 11 | Jennifer Aniston's character from her decade long show, who gave the world one of the most popular hairstyles in history: 2 wds. |
| 32% | STEVEWOZNIAK | 12 | Co-founder of Apple and noted philanthropist who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 32% | GEORGECLOONEY | 13 | American actor from "Up in the Air" who is a former UN messenger of peace and is a part of the "Not on Our Watch" organization: 2 wds. |
| 32% | CHILD | 5 | Lee ___, "One Shot" author who made a guest appearance in the book's film adaptation |
| 31% | DAVIDSCHWIMMER | 14 | Actor who had a capuchin monkey costar on "Friends": 2 wds. |
| 31% | SEANPENN | 8 | Actor famous for "Milk" and "Mystic River" who appeared as a guest star on "Friends": 2 wds. |
| 31% | BRADPITT | 8 | Actor famous for "Fight Club" and "Troy" who appeared as a guest star on "Friends": 2 wds. |
| 31% | ELONMUSK | 8 | CEO of SpaceX and product architect of Tesla who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 31% | ANDYSAMBERG | 11 | Actor who plays a wedding guest who's stuck in a time loop in 44-Across: 2 wds. |
| 30% | JULIAROBERTS | 12 | "Eat Pray Love" star, who made an appearance on NBC's "Running Wild with Bear Grylls" on Red Nose Day 2017: 2 wds. |
| 30% | JAMESBROLIN | 11 | Actor who played a physician on 28-Across: 2 wds. |
| 30% | EMMATHOMPSON | 12 | Actor from "Beauty and the Beast" who voiced a macaw named Polynesia in the 2020 film "Dolittle": 2 wds. |