| 100% | RUTHNEGGA | 9 | Actor in Loving, Preacher, Agents of S.H.I.E.L.D. |
| 67% | LUNA | 4 | Gabriel ___, "Marvel's Agents of S.H.I.E.L.D" actor who plays Tommy in HBO's "The Last of Us" |
| 66% | CLARKGREGG | 10 | "Agents of S.H.I.E.L.D." actor who plays Phil Coulson in "Captain Marvel": 2 wds. |
| 59% | CLARKGREGG | 10 | Actor who plays the character of Phil Coulson, a S.H.I.E.L.D agent in "Captain Marvel": 2 wds. |
| 59% | NICK | 4 | With 33-Across, agent of S.H.I.E.L.D. played by Samuel L. Jackson |
| 58% | ICER | 4 | Freezing weapon used in "Marvel's Agents of S.H.I.E.L.D." |
| 58% | ICER | 4 | "Freezing" weapon used in "Marvel's Agents of S.H.I.E.L.D." |
| 56% | HYDRA | 5 | Villainous organization in “Agents of S.H.I.E.L.D.” |
| 55% | HYDRA | 5 | Villainous organization in "Agents of S.H.I.E.L.D." |
| 55% | ABC | 3 | "Marvel's Agents of S.H.I.E.L.D." TV network |
| 54% | PATTON | 6 | Oswalt seen in A.P. Bio and Agents of S.H.I.E.L.D. |
| 53% | ABC | 3 | "Agents of S.H.I.E.L.D." channel |
| 53% | ABC | 3 | "Agents of S.H.I.E.L.D." network |
| 52% | JOSS | 4 | "Agents of S.H.I.E.L.D." cocreator Whedon |
| 52% | JOSS | 4 | "Agents of S.H.I.E.L.D." creator Whedon |
| 52% | CHLOE | 5 | "Agents of S.H.I.E.L.D." actress Bennet |
| 52% | ABC | 3 | "Agents of S.H.I.E.L.D." TV network |
| 52% | MELINDAMAY | 10 | Ming-Na Wen, on "Agents of S.H.I.E.L.D." |
| 52% | WEN | 3 | “Agents of S.H.I.E.L.D.” actress Ming-Na ___ |
| 52% | MING | 4 | “Agents of S.H.I.E.L.D.” actress ___-Na Wen |
| 52% | OTFAGBENLE | 10 | "The Handmaid's Tale" actor who plays a S.H.I.E.L.D. agent in 39-Across (2 wds.) |
| 51% | HYDRA | 5 | Terrorist group on "Agents of S.H.I.E.L.D." |
| 51% | SKYE | 4 | "Agents of S.H.I.E.L.D." character played by Chloe Bennet |
| 50% | AGT | 3 | Any mem. of S.H.I.E.L.D., e.g. |
| 49% | PHILCOULSON | 11 | Main character on ABC's "Marvel's Agents of S.H.I.E.L.D.": 2 wds. |
| 47% | COBIE | 5 | Smulders of How I Met Your Mother and Avengers: Agents of S.H.I.E.L.D. |
| 46% | WEN | 3 | Ming-Na __, star of Mulan, Agents of S.H.I.E.L.D. |
| 45% | WEN | 3 | Ming-Na of "Agents of S.H.I.E.L.D." |
| 45% | AGENTS | 6 | "Marvel's ___ of S.H.I.E.L.D." |
| 44% | AGENT | 5 | Employee of Marvel's S.H.I.E.L.D, e.g. |