| 100% | TIMCURRY | 8 | Actor known for playing Dr. Frank-N-Furter in "The Rocky Horror Picture Show" and the characters 15-Across, 29-Across, and 36-Across (2 wds.) |
| 56% | TIM | 3 | Actor Curry who played Dr. Frank N. Furter in "The Rocky Horror Picture Show" |
| 54% | TIMCURRY | 8 | "Clue" star who played Dr. Frank-N-Furter in "The Rocky Horror Picture Show": 2 wds. |
| 45% | BARRYBOSTWICK | 13 | "Scandal" actor who played Brad in "The Rocky Horror Picture Show": 2 wds. |
| 40% | MEATLOAF | 8 | Rock singer who played Eddie in "The Rocky Horror Picture Show": 2 wds. |
| 40% | SUSANSARANDON | 13 | Oscar-winning actress who played Janet in "The Rocky Horror Picture Show": 2 wds. |
| 37% | PETERSELLERS | 12 | Actor who played Pres. Merkin Muffley, Group Capt. Lionel Mandrake, and the title character in 32-Across: 2 wds. |
| 37% | EWANMCGREGOR | 12 | Actor who played 29-/32-Across in the 1990s and 2000s: 2 wds. |
| 37% | ALECGUINNESS | 12 | Actor who played 29-/32-Across in the 1970s and 1980s: 2 wds. |
| 37% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 37% | DENVERPYLE | 10 | TV actor known for playing 16-Across and 33-Across who would have turned 100 years old in 2020 (2 wds.) |
| 37% | TIMEWARP | 8 | Dance song in "The Rocky Horror Picture Show" (2 wds.) |
| 37% | STANLEYTUCCI | 12 | 19-Across and 32-Across actor who plays Dr. Abraham Erskine in "Captain America: The First Avenger" (2 wds.) |
| 37% | KYLEMACLACHLAN | 14 | Actor who is known for playing Special Agent Dale Cooper in the cult TV series "Twin Peaks": 2 wds. |
| 36% | ZACEFRON | 8 | 15-Across, 9-Down, and 22-Down actor who plays Troy Bolton in the "High School Musical" movies (2 wds.) |
| 36% | DANAASHBROOK | 12 | American actor known for playing Bobby Briggs in the cult TV series "Twin Peaks": 2 wds. |
| 36% | FREDSAVAGE | 10 | Actor who played Kevin Arnold in the original version of 36-Across and is coproducing the reboot: 2 wds. |
| 36% | HENRYCAVILL | 11 | Actor known for playing a DC superhero who will be seen in the new "Mission: Impossible" film: 2 wds. |
| 35% | TIMEWARP | 8 | 1970s novelty dance based on a song in "The Rocky Horror Picture Show": 2 wds. |
| 35% | CONNIENIELSEN | 13 | Actor playing 36 across in the upcoming movie "Wonder Woman": 2 wds. |
| 35% | ROBINWILLIAMS | 13 | Actor who played Daniel Hillard, and the title character, in the 1993 film "Mrs. Doubtfire": 2 wds. |
| 35% | MICHAELKEATON | 13 | Actor who shared SAG Awards for Outstanding Performance by an Ensemble in a Motion Picture with the casts of 18-Across and 33-Across (2 wds.) |
| 35% | PIERCEBROSNAN | 13 | Actor who plays 29-Across in "GoldenEye," "Tomorrow Never Dies," "The World Is Not Enough," and 15-Across (2 wds.) |
| 35% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 34% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane in "Frasier" and "Cheers", and hosted the 1998 Grammy Awards: 2 wds. |
| 34% | MATTSMITH | 9 | Eleventh actor to play the lead role in 15-Across (2010-2013): 2 wds. |
| 34% | DAVIDTENNANT | 12 | Tenth actor to play the lead role in 15-Across (2005-2010): 2 wds. |
| 34% | THEXFILES | 9 | Paranormal TV series featuring the characters 15-Across, 21-Across, and 41-Across that debuted in 1993 (2 wds.) |
| 34% | JONFAVREAU | 10 | Actor who plays Happy Hogan in Marvel films, and has directed the pilot for "The Orville": 2 wds. |
| 33% | LUCYLIU | 7 | 15-Across, 20-Across, and 36-Across actress who voices Master Viper in the "Kung Fu Panda" films (2 wds.) |