| 100% | WIL | 3 | Actor Wheaton who occasionally guest-stars on "The Big Bang Theory" |
| 87% | WIL | 3 | Actor Wheaton who's guest-starred on "The Big Bang Theory" |
| 84% | WIL | 3 | Actor Wheaton who has guest appearances on "The Big Bang Theory" |
| 72% | WIL | 3 | Actor Wheaton who made several guest appearances on "The Big Bang Theory" |
| 70% | WIL | 3 | "Star Trek: TNG" actor Wheaton who made several guest appearances on "The Big Bang Theory" |
| 64% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who guest stars as himself on "The Big Bang Theory" (2 wds.) |
| 64% | WIL | 3 | Wheaton who starred in The Big Bang Theory |
| 62% | WIL | 3 | Wheaton who plays himself on The Big Bang Theory |
| 61% | JUDDHIRSCH | 10 | "Superior Donuts" actor who guest stars as Leonard's dad on "The Big Bang Theory" (2 wds.) |
| 61% | TAKEI | 5 | "Star Trek" actor George who has had cameos on "The Big Bang Theory" and "King of the Nerds" |
| 61% | ADAMWEST | 8 | Batman actor from the 1960s who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 61% | WIL | 3 | Actor Wheaton with a recurring role on "The Big Bang Theory" |
| 60% | WIL | 3 | Actor Wheaton who had a recurring role on "The Big Bang Theory" |
| 59% | WIL | 3 | Wheaton with guest appearances on "The Big Bang Theory" |
| 56% | WIL | 3 | Wheaton who played himself on "The Big Bang Theory" |
| 55% | JIMPARSONS | 10 | Actor who plays Sheldon on "The Big Bang Theory" (2 wds.) |
| 55% | JOHNNYGALECKI | 13 | Actor who plays Leonard on "The Big Bang Theory" (2 wds.) |
| 54% | WIL | 3 | Wheaton who has appeared as himself on "The Big Bang Theory" |
| 54% | NYE | 3 | Scientist who guest-starred twice on “The Big Bang Theory” |
| 54% | KUNALNAYYAR | 11 | Actor who played Raj on “The Big Bang Theory” |
| 53% | HAWKING | 7 | Physicist Stephen, guested on The Big Bang Theory |
| 53% | LAURIEMETCALF | 13 | "Lady Bird" actress who guest stars as Sheldon's mom on "The Big Bang Theory" (2 wds.) |
| 52% | PARSONS | 7 | Jim who plays Sheldon on The Big Bang Theory |
| 52% | JIMPARSONS | 10 | "The Big Bang Theory" actor who played Michael in "The Boys in the Band": 2 wds. |
| 50% | JIMPARSONS | 10 | "The Big Bang Theory" actor who narrates 44-Across (2 wds.) |
| 49% | RAJ | 3 | Kunal Nayyar's character on The Big Bang Theory |
| 49% | BIALIK | 6 | The Big Bang Theory and Blossom star Mayim |
| 48% | BOB | 3 | Newhart who played Professor Proton on "The Big Bang Theory" |
| 48% | MAYIM | 5 | "The Big Bang Theory" actress __ Bialik who is also a scheduled 2021 "Jeopardy!" guest host |
| 48% | MAYIMBIALIK | 11 | Former "Blossom" and "The Big Bang Theory" star who co-hosts "Jeopardy!" (2 wds,) |