| 100% | JOSHBROLIN | 10 | Actor who's played both Thanos and Cable: 2 wds. |
| 75% | BENAFFLECK | 10 | Actor who's played both Daredevil and Batman: 2 wds. |
| 71% | RYANREYNOLDS | 12 | Actor who's played both Green Lantern and Deadpool: 2 wds. |
| 70% | CHRISEVANS | 10 | Actor who's played both Captain America and the Human Torch: 2 wds. |
| 63% | GARYBURGHOFF | 12 | Actor who played "Radar" O'Reilly in both the movie and TV series "M*A*S*H": 2 wds. |
| 62% | HALLEBERRY | 10 | Actress who's played both Storm and Catwoman: 2 wds. |
| 60% | MICHAELGROSS | 12 | Actor who played Burt Gummer in both the movie and TV series "Tremors": 2 wds. |
| 56% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 55% | RICORODRIGUEZ | 13 | Actor who plays Manny Delgado, Gloria's son and Jay's stepson, on "Modern Family": 2 wds. |
| 54% | JOSHBROLIN | 10 | Actor who plays Jonah Hex in a DC Comics film and Thanos in three Marvel films (2 wds.) |
| 54% | IDRISELBA | 9 | Actor who played Bloodsport in DC's "The Suicide Squad" and Heimdall in Marvel's "Thor": 2 wds. |
| 54% | DANSTEVENS | 10 | "Downton Abbey" actor who played the Beast in 2017's "Beauty and the Beast": 2 wds. |
| 54% | CHUCKCONNORS | 12 | Actor who was one of only 13 athletes to play in both the NBA and the MLB (2 wds.) |
| 53% | MICHAELPENA | 11 | "Ant-Man" actor who plays Dora's father in "Dora and the Lost City of Gold": 2 wds. |
| 53% | SCOTTMACARTHUR | 14 | "The Mick" actor who plays Isla's brother and general manager Ness Olson on "Running Point": 2 wds. |
| 53% | DJIMONHOUNSOU | 13 | Actor who played the wizard Shazam in DC's "Shazam!" and Korath in Marvel's "Guardians of the Galaxy": 2 wds. |
| 53% | DAVIDMCCALLUM | 13 | Actor who currently plays 15-Across and once played 50-Across: 2 wds. |
| 52% | TIMOTHYHUTTON | 13 | Actor who played Russ Skokie and Dan Sullivan on "American Crime": 2 wds. |
| 52% | EDDIEMURPHY | 11 | Actor who played Mama and Granny Klump in "The Nutty Professor": 2 wds. |
| 52% | KENNETHBRANAGH | 14 | Actor who played Hercule Poirot in 2017's "Murder on the Orient Express" and 2022's "Death on the Nile": 2 wds. |
| 52% | JUDDNELSON | 10 | Actor who played a high school delinquent in "The Breakfast Club" and a yuppie politician in "St. Elmo's Fire": 2 wds. |
| 52% | EMILIOESTEVEZ | 13 | Actor who played a high school jock in "The Breakfast Club" and a law student in "St. Elmo's Fire": 2 wds. |
| 52% | ADAMSANDLER | 11 | Actor who played Jill in "Jack and Jill": 2 wds. |
| 51% | HUGHLAURIE | 10 | "House" actor who plays keyboards and sings in Band From TV: 2 wds. |
| 51% | ALANRICKMAN | 11 | Actor who played Professor Snape and was a misunderstood character in "Harry Potter" series: 2 wds. |
| 51% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 51% | COLINHANKS | 10 | Actor who plays officer Gus Grimly in "Fargo" and whose father is Tom Hanks: 2 wds. |
| 51% | PATRICKSWAYZE | 13 | "Ghost" actor who played surfer and bank robber Bodhi in "Point Break": 2 wds. |
| 51% | MICHAELONTKEAN | 14 | "Slap Shot" actor who played Sheriff Harry S. Truman on "Twin Peaks": 2 wds. |
| 51% | CHRISPERFETTI | 13 | "Looking" actor who plays a history teacher and ally of 15-Across: 2 wds. |