| 100% | WARRENBEATTY | 12 | Actor who directed, wrote, and appears in "Rules Don't Apply": 2 wds. |
| 62% | ANNETTEBENING | 13 | Actress and wife of 18-Across, who also appears in "Rules Don't Apply": 2 wds. |
| 54% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 53% | HARVEYKEITEL | 12 | Actor who appeared completely nude in "Bad Lieutenant" and "The Piano": 2 wds. |
| 53% | ROBERTREDFORD | 13 | "All Is Lost" actor who directed and starred in "The Horse Whisperer": 2 wds. |
| 52% | EWANMCGREGOR | 12 | Actor who appeared completely nude in "Trainspotting" and "Velvet Goldmine": 2 wds. |
| 52% | WILLIAMSHATNER | 14 | "T.J. Hooker" actor who appeared on "The Twilight Zone" in 1960 and 1963: 2 wds. |
| 52% | BRADLEYCOOPER | 13 | "American Sniper" actor who directed and stars in the "A Star Is Born" remake: 2 wds. |
| 51% | LESLIENIELSEN | 13 | Actor who says, "I am serious ... and don't call me Shirley" in "Airplane!" (2 wds.) |
| 50% | NAVIDNEGAHBAN | 13 | Actor who appeared in "24," "Homeland" and is playing The Sultan in 2019 film "Aladdin": 2 wds. |
| 50% | JONFAVREAU | 10 | Actor who plays Happy Hogan in Marvel films, and has directed the pilot for "The Orville": 2 wds. |
| 49% | EDWARDNORTON | 12 | "Fight Club" actor who plays Lionel Essrog in "Motherless Brooklyn" and also directed the film: 2 wds. |
| 49% | DEANCAIN | 8 | "Lois & Clark" actor who appeared in Hallmark Channel films "Broadcasting Christmas" and "Winter's Dream": 2 wds. |
| 49% | PATRICKDUFFY | 12 | "Step by Step" actor who appeared in Hallmark Channel films "The Christmas Cure" and "Love Takes Wing": 2 wds. |
| 47% | ORSONWELLES | 11 | Actor who directed 17-Across and played the title character: 2 wds. |
| 46% | RONHOWARD | 9 | "Happy Days" actor who directed "Apollo 13" and "A Beautiful Mind": 2 wds. |
| 46% | ROBREINER | 9 | "All in the Family" actor who directed "The Princess Bride" and "When Harry Met Sally ...": 2 wds. |
| 46% | ADAMSANDLER | 11 | Actor who played Jill in "Jack and Jill": 2 wds. |
| 45% | LIEVSCHREIBER | 13 | "Ray Donovan" actor who appears in "Spotlight": 2 wds. |
| 45% | HOWARDHUGHES | 12 | Reclusive billionaire played by 18-Across in "Rules Don't Apply: 2 wds. |
| 45% | JADENSMITH | 10 | Actor who appeared in "After Earth" with his father Will: 2 wds. |
| 45% | BILLMURRAY | 10 | Oscar-nominated actor who has appeared in nine movies directed by 40-Across, including "The French Dispatch" (2 wds.) |
| 45% | ADRIENBRODY | 11 | Oscar-winning actor who has appeared in four movies directed by 40-Across, including "The French Dispatch" (2 wds.) |
| 45% | JODIEFOSTER | 11 | "Panic Room" actress who directed and starred in "Little Man Tate": 2 wds. |
| 45% | JOHNSTAMOS | 10 | "Full House" actor who appeared in commercials for Oikos Greek yogurt: 2 wds. |
| 45% | CHARLESBRONSON | 14 | "Death Wish" actor who appeared on "The Twilight Zone" in 1961: 2 wds. |
| 45% | EDDIEMURPHY | 11 | Actor who played Mama and Granny Klump in "The Nutty Professor": 2 wds. |
| 45% | ALANRICKMAN | 11 | "Die Hard" actor who played Colonel Brandon in "Sense and Sensibility": 2 wds. |
| 45% | JESSEPLEMONS | 12 | "Jungle Cruise" actor who plays Allan Gore in "Love and Death": 2 wds. |
| 44% | EWANMCGREGOR | 12 | Actor who played 29-/32-Across in the 1990s and 2000s: 2 wds. |