| 100% | AVERYBROOKS | 11 | Actor who played Captain Benjamin Sisko on "Star Trek: Deep Space Nine": 2 wds. |
| 78% | AVERYBROOKS | 11 | "Spenser: For Hire" actor who played Captain Sisko on "Star Trek: Deep Space Nine" (2 wds.) |
| 59% | COLMMEANEY | 10 | "Star Trek: Deep Space Nine" actor who plays Bernie Ohls in "Marlowe" (2 wds.) |
| 53% | PATRICKSTEWART | 14 | Actor who played Captain Jean-Luc Picard on "Star Trek: The Next Generation": 2 wds. |
| 49% | KATEMULGREW | 11 | Actress who played Captain Kathryn Janeway on "Star Trek: Voyager": 2 wds. |
| 49% | PATRICKSTEWART | 14 | "X-Men" actor who played Captain Picard on "Star Trek: The Next Generation" (2 wds.) |
| 48% | WILLIAMSHATNER | 14 | "Star Trek" star who played a murderous actor on "Columbo": 2 wds. |
| 45% | PETERKRAUSE | 11 | "Parenthood" actor who plays fire captain Robert Nash on "9-1-1": 2 wds. |
| 45% | ETHANPECK | 9 | "Star Trek: Discovery" actor who plays Spock on "Strange New Worlds": 2 wds. |
| 44% | CHACECRAWFORD | 13 | "Gossip Girl" actor who plays The Deep (aka Kevin Moskowitz) on "The Boys": 2 wds. |
| 44% | KATEMULGREW | 11 | "Orange Is the New Black" actress who played Captain Janeway on "Star Trek: Voyager" (2 wds.) |
| 44% | SHATNER | 7 | William ___, actor who played Captain Kirk on "Star Trek: The Original Series" |
| 43% | SISKO | 5 | "Star Trek: Deep Space Nine" captain played by Avery Brooks |
| 43% | JACKQUAID | 9 | "Star Trek: Lower Decks" actor who plays newbie vigilante Hughie Campbell on "The Boys": 2 wds. |
| 42% | PETERKRAUSE | 11 | "Parenthood" actor who plays fire captain Bobby Nash on "9-1-1" (2 wds.) |
| 42% | WENDELLPIERCE | 13 | "The Wire" actor who plays an NYPD captain on "Elsbeth" (2 wds.) |
| 42% | ICECUBE | 7 | Actor who plays Captain Dickson in "22 Jump Street": 2 wds. |
| 41% | WILLIAMSHATNER | 14 | Actor who first played James T. Kirk, the captain played by Chris Pine in the new "Star Trek" films (2 wds.) |
| 41% | MANNYJACINTO | 12 | Actor who played Yao on "Nine Perfect Strangers" and costarred in 29- and 42-Across: 2 wds. |
| 41% | CHIMCBRIDE | 10 | "Boston Public" actor who plays Captain Lou Grover on "Hawaii Five-0" (2 wds.) |
| 41% | DUSTINHOFFMAN | 13 | "Rain Man" actor who played Captain Hook in "Hook": 2 wds. |
| 41% | CARROLLOCONNOR | 14 | Actor who played Archie on 16-Across: 2 wds. |
| 41% | ANDYKAUFMAN | 11 | Actor who played Latka Gravas on "Taxi": 2 wds. |
| 41% | BILLYPORTER | 11 | Actor who plays Pray Tell on "Pose": 2 wds. |
| 41% | STEVECARELL | 11 | "The Office" actor who plays the first Chief of Space Operations on "Space Force" (2 wds.) |
| 41% | RICHARDKIND | 11 | "Spin City" actor who plays Captain Stan Yenko on 37-Across (2 wds.) |
| 40% | HARRYANDERSON | 13 | Actor who played Judge Stone on 18-Across: 2 wds. |
| 40% | DONADAMS | 8 | Actor who played Agent 86 on 16-Across: 2 wds. |
| 40% | WILLIAMDEVANE | 13 | Actor who played Greg Sumner on "Knots Landing": 2 wds. |
| 40% | CHARLIEHEATON | 13 | Actor who played Jonathan Byers on "Stranger Things": 2 wds. |