| 100% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane on "Frasier": 2 wds. |
| 81% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane in "Frasier" and "Cheers", and hosted the 1998 Grammy Awards: 2 wds. |
| 71% | MARKHARMON | 10 | "NCIS" actor who played Dr. Robert Caldwell on "St. Elsewhere": 2 wds. |
| 71% | OLIVERPLATT | 11 | "Huff" actor who plays Dr. Daniel Charles on "Chicago Med": 2 wds. |
| 70% | MARTINFREEMAN | 13 | "The Hobbit" actor who plays Dr. Watson on the BBC's "Sherlock": 2 wds. |
| 70% | JOHNMALKOVICH | 13 | "The New Pope" actor who plays Dr. Adrian Mallory on "Space Force": 2 wds. |
| 69% | HARRISONFORD | 12 | "1923" actor who plays Dr. Paul Rhoades on "Shrinking" (2 wds.) |
| 69% | OMIDABTAHI | 10 | "American Gods" actor who plays Dr. Pershing on "The Mandalorian" (2 wds.) |
| 68% | TIMROTH | 7 | "Pulp Fiction" actor who played Dr. Cal Lightman on the Fox series "Lie To Me": 2 wds. |
| 66% | RONLEIBMAN | 10 | "Norma Rae" actor who played Rachel's father, Dr. Leonard Green, on "Friends": 2 wds. |
| 66% | RYANEGGOLD | 10 | "The Blacklist" actor who plays Dr. Max Goodwin on "New Amsterdam" (2 wds.) |
| 66% | ROBERTSEAN | 10 | With 25-Across, actor who played Dr. James Wilson (based on 47-Across) on the Fox series "House": 2 wds. |
| 65% | JAMESBROLIN | 11 | "Life in Pieces" actor who played Dr. Steve Kiley on 30-Across (2 wds.) |
| 65% | ALEXKARRAS | 10 | Actor who played the adoptive father on "Webster": 2 wds. |
| 65% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 65% | DANNYDEVITO | 11 | Actor who played Louie De Palma on "Taxi": 2 wds. |
| 65% | TONYGOLDWYN | 11 | Actor who played President Fitzgerald Grant on "Scandal": 2 wds. |
| 65% | DENNISHAYSBERT | 14 | Actor who played President David Palmer on "24": 2 wds. |
| 64% | ANUPAMKHER | 10 | "Bend It like Beckham" actor who plays Dr. Vijay Kapoor on NBC's "New Amsterdam" (2 wds.) |
| 63% | KELSEYGRAMMER | 13 | Actor who reprises his role as psychologist Frasier Crane on "Frasier" (2 wds.) |
| 63% | MICHAELEALY | 11 | "Barbershop" actor who plays Detective Miles Hoffman on "Stumptown": 2 wds. |
| 63% | JEREMYSISTO | 11 | "Law & Order" actor who plays agent Jubal Valentine on "FBI": 2 wds. |
| 63% | JOHNNYDEPP | 10 | Actor who played Ichabod Crane in "Sleepy Hollow": 2 wds. |
| 63% | HARRYANDERSON | 13 | Actor who played Judge Stone on 18-Across: 2 wds. |
| 63% | DONADAMS | 8 | Actor who played Agent 86 on 16-Across: 2 wds. |
| 63% | WILLIAMDEVANE | 13 | Actor who played Greg Sumner on "Knots Landing": 2 wds. |
| 63% | CHARLIEHEATON | 13 | Actor who played Jonathan Byers on "Stranger Things": 2 wds. |
| 63% | JAMESBROLIN | 11 | Actor who played a physician on 28-Across: 2 wds. |
| 63% | PETERGRAVES | 11 | Actor who played Jim Phelps on "Mission: Impossible": 2 wds. |
| 63% | BOBDENVER | 9 | Actor who played Gilligan on "Gilligan's Island": 2 wds. |