| 100% | MICHAELOKEEFE | 13 | Actor who plays baseball player Darryl Palmer in "The Slugger's Wife" and aspiring golfer Danny Noonan in 43-Across (2 wds.) |
| 42% | DUSTINHOFFMAN | 13 | Actor who played 43-Across in the movie "All the President's Men": 2 wds. |
| 42% | BURTLANCASTER | 13 | Actor who played baseball's Jim Thorpe in the 1951 biopic "Jim Thorpe — All-American": 2 wds. |
| 41% | JIMCARREY | 9 | "Dumb and Dumber" actor who played The Riddler in 43-Across (2 wds.) |
| 40% | GARYBURGHOFF | 12 | Actor who played "Radar" O'Reilly in both the movie and TV series "M*A*S*H": 2 wds. |
| 40% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 39% | GEORGECLOONEY | 13 | Actor who played Danny Ocean in the Ocean's trilogy: 2 wds. |
| 39% | FREDSAVAGE | 10 | Actor who played Kevin Arnold in the original version of 36-Across and is coproducing the reboot: 2 wds. |
| 39% | JOHNCORBETT | 11 | "Sex and the City" actor who plays Rebel's husband Grady in "Rebel": 2 wds. |
| 39% | EWANMCGREGOR | 12 | Actor who played 29-/32-Across in the 1990s and 2000s: 2 wds. |
| 39% | ALECGUINNESS | 12 | Actor who played 29-/32-Across in the 1970s and 1980s: 2 wds. |
| 39% | RUSSELLCROWE | 12 | "Thor: Love and Thunder" actor who plays Kraven's father Nikolai in "Kraven the Hunter": 2 wds. |
| 39% | JOHNTRAVOLTA | 12 | Actor who played high schooler Danny Zuko in the 1978 movie musical "Grease": 2 wds. |
| 39% | DANIELBRUHL | 11 | "The Zookeeper's Wife" actor who plays Laszlo Kreizler in 40-Across (2 wds.) |
| 38% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 38% | TONYDANZA | 9 | "The Good Cop" actor who played a former pro baseball player on "Who's the Boss?": 2 wds. |
| 38% | JASONROBARDS | 12 | Actor who played 15-Across in the 1967 film "The St. Valentine's Day Massacre": 2 wds. |
| 38% | KENNETHBRANAGH | 14 | Actor who played Hercule Poirot in 2017's "Murder on the Orient Express" and 2022's "Death on the Nile": 2 wds. |
| 38% | JUDDNELSON | 10 | Actor who played a high school delinquent in "The Breakfast Club" and a yuppie politician in "St. Elmo's Fire": 2 wds. |
| 38% | EMILIOESTEVEZ | 13 | Actor who played a high school jock in "The Breakfast Club" and a law student in "St. Elmo's Fire": 2 wds. |
| 38% | MATTSMITH | 9 | Actor who played Prince Philip, Duke of Edinburgh in the historical drama TV series "The Crown" and also starred in "Party Animals" as Danny Foster: 2 wds. |
| 38% | DANSTEVENS | 10 | "Downton Abbey" actor who played the Beast in 2017's "Beauty and the Beast": 2 wds. |
| 38% | MATTDAMON | 9 | Actor who plays rugby player Francois Pienaar in the 2009 film "Invictus" (2 wds.) |
| 38% | TOMMYLEEJONES | 13 | Actor who played baseball's Ty Cobb in the 1994 biopic "Cobb": 3 wds. |
| 38% | DJIMONHOUNSOU | 13 | Actor who played the wizard Shazam in DC's "Shazam!" and Korath in Marvel's "Guardians of the Galaxy": 2 wds. |
| 38% | PETERSELLERS | 12 | Actor who played Pres. Merkin Muffley, Group Capt. Lionel Mandrake, and the title character in 32-Across: 2 wds. |
| 37% | MICHAELPENA | 11 | "Ant-Man" actor who plays Dora's father in "Dora and the Lost City of Gold": 2 wds. |
| 37% | MORGANFREEMAN | 13 | Oscar-winning actor who played 43-Across in the 2009 film "Invictus" (2 wds.) |
| 37% | ROBINWRIGHT | 11 | Actor from "Forrest Gump", who plays the wife of the character played by 18-Across in "House of Cards": 2 wds. |
| 37% | ROBINWILLIAMS | 13 | Actor who played Daniel Hillard, and the title character, in the 1993 film "Mrs. Doubtfire": 2 wds. |