| 100% | RONEELY | 7 | Actor who plays slippery characters? |
| 68% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 68% | DEPP | 4 | Actor who played the famous character of Jack Sparrow, Johnny ___ |
| 66% | CHACECRAWFORD | 13 | Actor who plays the key male character in "Gossip Girl": 2 wds. |
| 65% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 65% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 64% | ROBERTDENIRO | 12 | "Joy" actor who plays the title character in 18-Across: 3 wds. |
| 64% | PEDROPASCAL | 11 | "Narcos" actor who plays the title character on "The Mandalorian" (2 wds.) |
| 64% | WALTONGOGGINS | 13 | "Justified" actor who plays the main character Wade on 18-Across: 2 wds. |
| 63% | DONJOHNSON | 10 | "Miami Vice" actor who played the title character on 40-Across (2 wds.) |
| 63% | ALANRICKMAN | 11 | Actor who played Professor Snape and was a misunderstood character in "Harry Potter" series: 2 wds. |
| 63% | REBBROWN | 8 | Actor who played the titular character in the TV movie "Captain America" in 1979: 2 wds. |
| 63% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 63% | CHAR | 4 | Actor who played a character with the same first name on "Two and a Half Men" |
| 63% | MCGREGOR | 8 | Ewan ___, actor who plays the titular character in the TV series "Obi-Wan Kenobi" |
| 63% | MATTHEW | 7 | ___ Rhys, "The Americans" actor who plays the titular character in HBO's "Perry Mason" |
| 63% | TED | 3 | ___ Danson, actor who played the main character Sam Malone in the '80s sitcom "Cheers" |
| 62% | ORSONWELLES | 11 | Actor who directed 17-Across and played the title character: 2 wds. |
| 62% | BENMENDELSOHN | 13 | Actor who plays the character of Talos, a shape shifting Skrull leader in "Captain Marvel": 2 wds. |
| 62% | MELGIBSON | 9 | Actor who played the lead character, "Mad" Max Rockatansky in the 1979 film "Mad Max": 2 wds. |
| 62% | ROBINWILLIAMS | 13 | Actor who played Daniel Hillard, and the title character, in the 1993 film "Mrs. Doubtfire": 2 wds. |
| 62% | TARONEGERTON | 12 | "Kingsman: The Golden Circle" actor who plays the title character in 16-Across: 2 wds. |
| 62% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |
| 62% | TIMOTHEE | 8 | With 35-Across, "Little Women" actor who plays the lead character Paul Atreides in "Dune" |
| 62% | PETERDINKLAGE | 13 | "Game of Thrones" actor who plays the title character in "The Toxic Avenger": 2 wds. |
| 62% | DAVID | 5 | ___ Ackroyd, actor who played the titular character in the TV movie "Exo-Man" in 1977 |
| 61% | EDASNER | 7 | Actor who won Emmys for playing the same character on two different shows |
| 61% | ANSELELGORT | 11 | "The Fault in Our Stars" actor who plays the title character in "Baby Driver": 2 wds. |
| 61% | CHRISTIANKANE | 13 | The actor who plays the lead character and genius Jacob Stone on "The Librarians": 2 wds. |
| 61% | ANTHONYRAMOS | 12 | "A Star Is Born" actor who plays Usnavi, the lead character in 18-Across: 2 wds. |