| 100% | ASHTONKUTCHER | 13 | Actor who succeeded Charlie Sheen on 23-/38-Across: 2 wds. |
| 62% | ASHTONKUTCHER | 13 | Actor who replaced Charlie Sheen on "Two and a Half Men": 2 wds. |
| 52% | EMILIOESTEVEZ | 13 | Charlie Sheen's brother who's also an actor: 2 wds. |
| 46% | HOLLANDTAYLOR | 13 | Evelyn Harper portrayer on 23-/38-Across: 2 wds. |
| 45% | BRUCEWILLIS | 11 | Actor who played David Dunn in 38-Across: 2 wds. |
| 45% | HARRYANDERSON | 13 | Actor who played Judge Stone on 18-Across: 2 wds. |
| 45% | BENFELDMAN | 10 | Actor who plays Jonah Simms on 17-Across: 2 wds. |
| 45% | DONADAMS | 8 | Actor who played Agent 86 on 16-Across: 2 wds. |
| 45% | JAMESBROLIN | 11 | Actor who played a physician on 28-Across: 2 wds. |
| 45% | CARROLLOCONNOR | 14 | Actor who played Archie on 16-Across: 2 wds. |
| 43% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title role on 16-Across: 2 wds. |
| 43% | JACKCOLEMAN | 11 | "Dynasty" actor who plays Noah Bennet on 30-/32-Across: 2 wds. |
| 43% | ZACHARYLEVI | 11 | "Chuck" actor who plays Luke Collins on 30-/32-Across: 2 wds. |
| 43% | DEANCAIN | 8 | Actor who played Superman on TV's "Lois & Clark": 2 wds. |
| 43% | JASONSUDEIKIS | 13 | Actor who plays Coach Ted Lasso on "Ted Lasso": 2 wds. |
| 43% | HARRYSHEARER | 12 | Actor who voices Principal Seymour Skinner on "The Simpsons": 2 wds. |
| 43% | ZACHARYLEVI | 11 | "Chuck" actor who plays the grown-up superhero version of 38-Across in "Shazam!": 2 wds. |
| 43% | RYANEGGOLD | 10 | "The Blacklist" actor who currently stars on 25-Across: 2 wds. |
| 43% | DAVEEDDIGGS | 11 | "Hamilton" actor who plays Andre Layton on 13-Across: 2 wds. |
| 43% | MRT | 3 | Actor who played B.A. on "The A-Team": 2 wds. |
| 43% | GERALDMCRANEY | 13 | "Major Dad" actor who costars on 18-Across: 2 wds. |
| 43% | CRESSWILLIAMS | 13 | "Black Lightning" actor who costars on 15-Across: 2 wds. |
| 42% | TIMMATHESON | 11 | "Hart of Dixie" actor who plays Doc Mullins on 38-Across (2 wds.) |
| 42% | DANIELCRAIG | 11 | "Skyfall" actor who turned 50 on March 2, 2018 (2 wds.) |
| 42% | STEVECARELL | 11 | "Foxcatcher" actor who starred on TV's "The Office": 2 wds. |
| 42% | BRENDANFRASER | 13 | "The Mummy" actor who plays Robotman on "Doom Patrol": 2 wds. |
| 42% | GREGKINNEAR | 11 | "Little Miss Sunshine" actor who costarred on "Shining Vale": 2 wds. |
| 42% | KEITHDAVID | 10 | "Greenleaf" actor who costars on "The Lowdown": 2 wds. |
| 42% | SEANGIAMBRONE | 13 | Actor who plays the geeky boy, Adam, on 18-Across: 2 wds. |
| 42% | JONATHANGROFF | 13 | Actor who originated the role of 15-Across on Broadway (2 wds.) |