| 100% | JUNELOCKHART | 12 | Actress of the month who played the mother on "Lassie": 2 wds. |
| 80% | JANUARYJONES | 12 | Actress of the month who played Betty Francis on "Mad Men": 2 wds. |
| 68% | MOLLYSHANNON | 12 | "Divorce" actress who plays the mother of the siblings on 36-Across (2 wds.) |
| 65% | LESLIEJONES | 11 | Actress who plays the mother of Prince Akeem's son in "Coming 2 America": 2 wds. |
| 64% | SUSANCLARK | 10 | Actress who played the adoptive mother on the 1980s sitcom "Webster": 2 wds. |
| 64% | ANGELABASSETT | 13 | Actress who plays the queen mother of Wakanda in "Black Panther": 2 wds. |
| 63% | LESLIEJONES | 11 | "Ghostbusters" actress who plays the mother of Prince Akeem's son in "Coming 2 America": 2 wds. |
| 62% | ANNAFARIS | 9 | Actress who played Christy Plunkett on the first seven seasons of the CBS sitcom "Mom": 2 wds. |
| 62% | RACHELMCADAMS | 13 | "The Notebook" actress who plays Ani Bezzerides on the latest season of "True Detective": 2 wds. |
| 62% | SHIRLEYJONES | 12 | Stepmother of 19-Across who played his mother on "The Partridge Family": 2 wds. |
| 61% | DIANEKEATON | 11 | Actress who plays a mother in "Father of the Bride" (2 wds.) |
| 61% | SUSIEESSMAN | 11 | Actress who plays the foul-mouthed wife of the main character's manager Jeff on "Curb Your Enthusiasm": 2 wds. |
| 61% | CHRISTINARICCI | 14 | "Z: The Beginning of Everything" actress who plays adult Misty on "Yellowjackets" (2 wds.) |
| 60% | CHARLOTTERAE | 12 | Actress who played Mrs. Garrett on "The Facts of Life": 2 wds. |
| 60% | ALEXISBLEDEL | 12 | "The Sisterhood of the Traveling Pants" actress who played daughter Rory on 14-Across: 2 wds. |
| 60% | EMILIACLARKE | 12 | "Me Before You" lead actress, who plays the role of Khaleesi, Mother of Dragons, in "Game of Thrones" : 2 wds. |
| 60% | KATEYSAGAL | 10 | "Sons of Anarchy" actress who played Penny's mother on "The Big Bang Theory" (2 wds.) |
| 59% | SHIRLEYJONES | 12 | Actress/singer who played the mom on "The Partridge Family": 2 wds. |
| 59% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 59% | EVALONGORIA | 11 | "Overboard" actress who plays Dora's mother in "Dora and the Lost City of Gold": 2 wds. |
| 59% | TOKSOLAGUNDOYE | 14 | Actress who plays the head of an Ivy League psychology department on "Frasier" (2 wds.) |
| 59% | LISAWHELCHEL | 12 | Actress who played Blair on "The Facts of Life": 2 wds. |
| 59% | KIMFIELDS | 9 | Actress who played Tootie on "The Facts of Life": 2 wds. |
| 59% | MINDYCOHN | 9 | Actress who played Natalie on "The Facts of Life": 2 wds. |
| 59% | BILLIEPIPER | 11 | "Doctor Who" actress who plays Isadora Capri, the head of music at Nevermore Academy, on "Wednesday": 2 wds. |
| 58% | LYNDACARTER | 11 | "Wonder Woman" actress who plays the President of the United States on "Supergirl" (2 wds.) |
| 58% | DIANNEWIEST | 11 | "Bullets Over Broadway" Oscar winner who plays the mother on 29-/32-Across: 2 wds. |
| 58% | SARAHCHALKE | 11 | "Scrubs" actress who plays Kate Mularkey on the Netflix adaptation of 41-Across (2 wds.) |
| 58% | SORCHACUSACK | 12 | "A Discovery of Witches" actress who plays the parish secretary on "Father Brown" (2 wds.) |
| 58% | CHRISTINARICCI | 14 | "Z: The Beginning of Everything" actress who plays adult Misty on 50-Across (2 wds.) |