| 100% | STORMREID | 9 | Actress playing Meg Murry in "A Wrinkle in Time": 2 wds. |
| 74% | OPRAHWINFREY | 12 | Actress playing Mrs. Which in "A Wrinkle in Time": 2 wds. |
| 73% | CHRISPINE | 9 | Actor playing Dr. Alex Murry in "A Wrinkle in Time": 2 wds. |
| 69% | MINDYKALING | 11 | Actress who plays Mrs. Who in "A Wrinkle in Time" (2 wds.) |
| 69% | OPRAHWINFREY | 12 | Actress who plays Mrs. Which in "A Wrinkle in Time" (2 wds.) |
| 62% | MINDYKALING | 11 | "A Wrinkle in Time" actress who plays Amita in "Ocean's 8" (2 wds.) |
| 61% | MINDYKALING | 11 | "A Wrinkle in Time" actress who plays new writer Molly Patel in "Late Night" (2 wds.) |
| 61% | STORMREID | 9 | "A Wrinkle in Time" actress who plays Jack Radcliff's niece in 35-Across (2 wds.) |
| 57% | CRISTINMILIOTI | 14 | Actress who plays a wedding guest who's stuck in a time loop in 44-Across: 2 wds. |
| 56% | SHARONTATE | 10 | Actress played by 42-Across in "Once Upon a Time in Hollywood" (2 wds.) |
| 55% | PINE | 4 | Actor Chris who plays Mr. Murry in "A Wrinkle in Time" |
| 54% | OPRAH | 5 | Actress Winfrey who plays Mrs. Which in "A Wrinkle in Time" |
| 53% | MARGOTROBBIE | 12 | "Once Upon a Time in Hollywood" actress who plays Kayla Pospisil in "Bombshell" (2 wds.) |
| 53% | ANYATAYLORJOY | 13 | "Glass" actress who played 19-Across in a 2020 film: 2 wds., hyph. |
| 53% | TESSATHOMPSON | 13 | "Thor: Ragnarok" actress who plays a surveyor in "Annihilation": 2 wds. |
| 53% | NATALIEPORTMAN | 14 | "Black Swan" actress who plays a biologist in "Annihilation": 2 wds. |
| 53% | MARGOTROBBIE | 12 | Actress who plays a fictional associate producer in "Bombshell": 2 wds. |
| 53% | GWYNETHPALTROW | 14 | "Shakespeare in Love" actress who played 19-Across in a 1996 film: 2 wds. |
| 53% | LUPITANYONGO | 12 | "12 Years a Slave" actress playing Nakia in 18-Across: 2 wds. |
| 52% | ONCUE | 5 | Perfectly timed, as in a play: 2 wds. |
| 52% | JERYLPRESCOTT | 13 | Actress who plays Madame Xanadu, a blind fortune teller, in the show in 18a: 2 wds. |
| 52% | ZOESALDANA | 10 | Actress who has played Gamora, a green superwoman in various Marvel movies: 2 wds. |
| 51% | DANIARAMIREZ | 12 | "Devious Maids" actress who plays Cinderella on "Once Upon a Time": 2 wds. |
| 51% | WINONARYDER | 11 | "Edward Scissorhands" actress, who plays a lead role in "Stranger Things": 2 wds. |
| 51% | KATEYSAGAL | 10 | "Sons of Anarchy" actress who plays a police officer in "Superior Donuts": 2 wds. |
| 51% | GRACEKELLY | 10 | Actress who played a socialite in Hitchcock's "Dial M for Murder": 2 wds. |
| 51% | DIANNEWIEST | 11 | "Bullets Over Broadway" actress who plays a grandma on "Life in Pieces": 2 wds. |
| 51% | AUBREYPLAZA | 11 | Actress who plays a profane 14th-century nun in "The Little Hours": 2 wds. |
| 50% | XOCHITLGOMEZ | 12 | "The Baby-Sitters Club" actress who plays a time-traveling teenager in "Doctor Strange in the Multiverse of Madness" (2 wds.) |
| 50% | MERYLSTREEP | 11 | Actress nominated for an Oscar for playing a music teacher in "Music of the Heart": 2 wds. |