| 100% | DEE | 3 | Actress Sandra who was the first to play "Gidget" |
| 100% | DEE | 3 | Actress Sandra who was the first to play Gidget |
| 81% | DEE | 3 | Sandra who was the first to play "Gidget" |
| 63% | ANDREAMCARDLE | 13 | Tony-nominated actress who was the first to play 40-Across on Broadway (2 wds.) |
| 62% | NIMOY | 5 | Actor Leonard who was the first to play Spock |
| 62% | ALYN | 4 | Kirk ___, actor who was the first to play Superman |
| 62% | ALEC | 4 | Baldwin who was the first to play Jack Ryan |
| 61% | ALEC | 4 | Actor Guinness who was the first to play Obi-Wan Kenobi |
| 61% | TOBEY | 5 | Actor Maguire who was the first to play Spider-Man in movies |
| 57% | DEE | 3 | Actress Sandra who was married to singer Bobby Darin in the '60s |
| 57% | HAYES | 5 | Helen who was the first actress to achieve the EGOT |
| 57% | IRA | 3 | Aldridge who was the first Black actor to play Othello |
| 57% | HATTIE | 6 | Actress McDaniel who was the first African-American to win an Academy Award |
| 57% | REBA | 4 | Singer McEntire who was the first woman to play Colonel Sanders |
| 57% | LORRE | 5 | Peter who was the first actor to play a Bond villain |
| 57% | SALONGA | 7 | Lea who was the first Asian actress to win a Tony |
| 56% | HAYES | 5 | Actress Helen who was the first person to win the Triple Crown of Acting |
| 56% | VIOLA | 5 | Actress Davis who was the first African American to win the Triple Crown of Acting |
| 55% | BENNYGOODMAN | 12 | Big Band bandleader who was the first jazz bandleader to play Carnegie Hall (2 wds.) |
| 55% | DANDRIDGE | 9 | Singer Dorothy who was the first African-American to get a Best Actress Oscar nomination |
| 54% | JACOBY | 6 | Ellsbury who was the first Native American of Navajo descent to play in Major League Baseball |
| 54% | BRYANT | 6 | Kobe ___, former Los Angeles Lakers player who was the first guard to play 20 seasons in NBA |
| 51% | BIGMAMATHORNTON | 15 | Singer who was the first to record “Hound Dog” |
| 51% | TINAFEY | 7 | Actress/writer who was the first woman to be head writer of "Saturday Night Live," and the third woman to host five times (2 wds.) |
| 51% | DEE | 3 | Sandra —, actress who played the title role in 1959 film comedy Gidget |
| 51% | LUPITANYONGO | 12 | "12 Years a Slave," 18-Across, and 32-Across star who was the first Kenyan-Mexican actress to win an Oscar (2 wds.) |
| 51% | CANDICEBERGEN | 13 | Actress who was the first woman to host "Saturday Night Live," and the first woman to host five times (2 wds.) |
| 51% | MELALLEN | 8 | Announcer who was the first to call DiMaggio "Joltin' Joe" |
| 50% | ALEX | 4 | Honnold who was the first to free-solo climb El Capitan |
| 50% | SAINTLEO | 8 | Fifth-century pope who was the first to be called "the Great" |