| 100% | LUCYLIU | 7 | Actress who played Joan (based on 47-Across) on the CBS series "Elementary": 2 wds. |
| 67% | NATALIEDORMER | 13 | "Game of Thrones" actress who played 32-Across on the CBS series "Elementary" (2 wds.) |
| 66% | LUCYLIU | 7 | Actress who plays 22-Across/41-Across on the CBS series "Elementary" (2 wds.) |
| 61% | HILARYSWANK | 11 | "Amelia" actress who plays an astronaut heading to Mars on the Netflix series "Away": 2 wds. |
| 59% | UZOADUBA | 8 | "In Treatment" actress who plays a detective on the Netflix series "The Residence": 2 wds. |
| 59% | LUCYLIU | 7 | Actress who plays 22-Across/41-Across in the CBS series "Elementary" (2 wds.) |
| 59% | MARYMCDONNELL | 13 | "Major Crimes" actress who plays Mary Dove Shaw on the CBS series "Tracker" (2 wds.) |
| 58% | ROBERTSEAN | 10 | With 25-Across, actor who played Dr. James Wilson (based on 47-Across) on the Fox series "House": 2 wds. |
| 58% | BARBARABAIN | 11 | Actress who played Cinnamon Carter on the 1966-1973 series "Mission: Impossible": 2 wds. |
| 58% | EMMACORRIN | 10 | "Lady Chatterley's Lover" actress who plays Princess Diana on the Netflix series "The Crown": 2 wds. |
| 58% | ERICADURANCE | 12 | "Saving Hope" actress who played Lois Lane on the 2001-2011 series "Smallville": 2 wds. |
| 58% | KATHRYNHAHN | 11 | "WandaVision" actress who plays advice columnist Clare Pierce in the Hulu series "Tiny Beautiful Things," based on a book by 30-Across (2 wds.) |
| 57% | LARAPULVER | 10 | "Spooks" actress who played 32-Across on the BBC series "Sherlock" (2 wds.) |
| 57% | JENNAORTEGA | 11 | "Scream" actress who plays Wednesday Addams on the Netflix series "Wednesday": 2 wds. |
| 57% | ELLAPURNELL | 11 | "Yellowjackets" actress who plays Lucy MacLean on the Amazon series "Fallout": 2 wds. |
| 56% | EARTHAKITT | 10 | Actress who played Catwoman on the 1960s TV series "Batman": 2 wds. |
| 56% | TAMARATUNIE | 11 | "Law & Order: SVU" actress who plays Anita Dupree on the CBS soap opera "Beyond the Gates": 2 wds. |
| 56% | ANNAFARIS | 9 | Actress who played Christy Plunkett on the first seven seasons of the CBS sitcom "Mom": 2 wds. |
| 56% | KRISTENBELL | 11 | "The Good Place" actress who plays Joanne on the Netflix series "Nobody Wants This": 2 wds. |
| 54% | PAGETBREWSTER | 13 | Actress who plays Emily Prentiss on 47-Across (2 wds.) |
| 54% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 54% | LILYJAMES | 9 | "Downton Abbey" actress who plays Pamela Anderson on the Hulu series "Pam & Tommy" (2 wds.) |
| 54% | RUBYROSE | 8 | "Orange Is the New Black" actress who plays Kate Kane on 14-Across: 2 wds. |
| 54% | EMMATHOMPSON | 12 | Actress who plays the protagonist in "Nanny McPhee and the Big Bang," which is based on the "Nurse Matilda" books: 2 wds. |
| 54% | LUCYLIU | 7 | Actress who plays Joan Watson on "Elementary" (2 wds.) |
| 54% | EMILYMEADE | 10 | Actress who plays Aimee, Jill's high school friend on the hit TV series "The Leftovers": 2 wds. |
| 54% | MADISONLINTZ | 12 | "The Walking Dead" actress who plays Maddie Bosch on the Amazon series "Bosch" (2 wds.) |
| 53% | ALEXISBLEDEL | 12 | "The Sisterhood of the Traveling Pants" actress who played daughter Rory on 14-Across: 2 wds. |
| 53% | HOPEDAVIS | 9 | "For the People" actress who plays mob wife Gina Baxter on 15-Across: 2 wds. |
| 53% | TAISSAFARMIGA | 13 | "American Horror Story" actress who plays the naive Gladys Russell on 17-Across: 2 wds. |