| 100% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 74% | DANIELKALUUYA | 13 | Actor who plays Slim, one of the title characters on the run in 2019's "Queen & Slim": 2 wds. |
| 65% | ISABELSANFORD | 13 | Actress who played Louise Jefferson, the main character on the '70s sitcom "The Jeffersons" which is one of the longest-running sitcoms: 2 wds. |
| 61% | WARREN | 6 | With 35-Across, actor who played Clyde, one of the title characters on the run in 1967's "Bonnie and Clyde" |
| 52% | BRIELARSON | 10 | Actress who plays the character of Carol Danvers, a former U.S. Air Force pilot in "Captain Marvel": 2 wds. |
| 52% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character in Netflix's "Ratched": 2 wds. |
| 52% | SUSIEESSMAN | 11 | Actress who plays the foul-mouthed wife of the main character's manager Jeff on "Curb Your Enthusiasm": 2 wds. |
| 52% | FAYEDUNAWAY | 11 | "Network" actress who played the fiancée of Paul Newman's architect character in "The Towering Inferno": 2 wds. |
| 52% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 52% | CAMILLERAZAT | 12 | Actress who plays the title character's new friend on 46-Across (2 wds.) |
| 51% | ROXIEROKER | 10 | Actress who played Helen Willis, the friendly neighbor in the '70s sitcom "The Jeffersons" which is one of the longest-running sitcoms: 2 wds. |
| 51% | LINDALAVIN | 10 | Actress who played the title character on the sitcom "Alice": 2 wds. |
| 50% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 50% | EDIEFALCO | 9 | "The Sopranos" actress who played the title character on "Nurse Jackie": 2 wds. |
| 50% | ANNEHATHAWAY | 12 | "Interstellar" actress who appears in one of the stories on 27-Across (2 wds.) |
| 49% | BARBARABARRIE | 13 | "Breaking Away" actress who played the title character's Nana on 46-Across (2 wds.) |
| 49% | CHERYLHINES | 11 | Actress who plays the main character's ex-wife on "Curb Your Enthusiasm": 2 wds. |
| 49% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 49% | FELICITYJONES | 13 | Actress who played Ruth Bader Ginsburg in the film "On the Basis of Sex": 2 wds. |
| 49% | FELICITYJONES | 13 | "Rogue One" actress who plays Ruth Bader Ginsburg in "On the Basis of Sex" (2 wds.) |
| 49% | ISABELSANFORD | 13 | Actress who played Louise on "All in the Family" and 45-Across (2 wds.) |
| 48% | LILYCOLLINS | 11 | Actress who plays the title character on 46-Across (2 wds.) |
| 48% | LESLIEJONES | 11 | Actress who plays the mother of Prince Akeem's son in "Coming 2 America": 2 wds. |
| 48% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 48% | RENEEZELLWEGER | 14 | Actress who returns to play the title character in "Bridget Jones: Mad About the Boy": 2 wds. |
| 48% | PETERDINKLAGE | 13 | "Game of Thrones" actor who plays the title character in "The Toxic Avenger": 2 wds. |
| 48% | LIZZYCAPLAN | 11 | "Masters of Sex" actress who plays one of Toby Fleishman's best friends on "Fleishman Is in Trouble" (2 wds.) |
| 48% | EMILYBLUNT | 10 | "The Girl on the Train" star who plays the title character in "Mary Poppins Returns": 2 wds. |
| 48% | TIFFANYHADDISH | 14 | "Keanu" actress who adopted one of the cats that played Keanu in the film: 2 wds. |
| 47% | CLARKGREGG | 10 | Actor who plays the character of Phil Coulson, a S.H.I.E.L.D agent in "Captain Marvel": 2 wds. |