| 100% | ALIWONG | 7 | Actress who played Sasha opposite Keanu Reeves in "Always Be My Maybe": 2 wds. |
| 62% | CHARLIZETHERON | 14 | Actress who played Sara opposite Keanu Reeves in "Sweet November": 2 wds. |
| 62% | CARRIEANNEMOSS | 14 | Actress who played Trinity opposite Keanu Reeves in "The Matrix": 2 wds., hyph. |
| 47% | KEANU | 5 | Reeves who played himself in "Always Be My Maybe" |
| 46% | WHITNEYHOUSTON | 14 | Singer and actress who played Rachel Marron in 18a and whose cover of "I Will Always Love You" became a best-selling single: 2 wds. |
| 45% | KEANU | 5 | Actor Reeves who played himself in "Always Be My Maybe" |
| 45% | SANDRA | 6 | With 40-Across, actress who played Kate opposite Keanu Reeves in "The Lake House" |
| 45% | CASEY | 5 | ___ Wilson, actress who played Chloe in 2019's "Always Be My Maybe" |
| 45% | GRACEKELLY | 10 | Actress who played sheriff Will Kane's wife in "High Noon": 2 wds. |
| 44% | DAKOTAJOHNSON | 13 | Actress who will play Anastasia Steele in 18-Across: 2 wds. |
| 44% | LEAMICHELE | 10 | Actress who plays 17-Across' girlfriend and was 29-Across' girlfriend in real life: 2 wds. |
| 43% | LETITIAWRIGHT | 13 | Actress who plays Shuri in the Marvel Cinematic Universe and has been on "Black Mirror": 2 wds. |
| 43% | ALI | 3 | ___ Wong, actress who played the female protagonist in 2019's "Always Be My Maybe" |
| 43% | MIAWASIKOWSKA | 13 | Actress who played the daughter of 14- and 32-Across in "The Kids Are All Right": 2 wds. |
| 43% | KATEMULGREW | 11 | Actress who played Galina "Red" Reznikov, an inmate in the TV series "Orange Is the New Black": 2 wds. |
| 42% | AMYPOEHLER | 10 | Actress who played the role of Leslie Knope in "Parks and Recreation", a role she is best-known for: 2 wds. |
| 42% | LAURAPREPON | 11 | Actress who played Alex Vause, an inmate in the TV series "Orange Is the New Black": 2 wds. |
| 42% | NATASHALYONNE | 13 | Actress who played Nicky Nichols, an inmate in the TV series "Orange Is the New Black": 2 wds. |
| 42% | SHERILYNFENN | 12 | Actress who is known for playing Audrey Horne in the cult TV series "Twin Peaks": 2 wds. |
| 42% | CHRISSYMETZ | 11 | Actress who plays Kate Pearson in NBC's "This Is Us" (2 wds.) |
| 41% | EMMATHOMPSON | 12 | Actress who plays the protagonist in "Nanny McPhee and the Big Bang," which is based on the "Nurse Matilda" books: 2 wds. |
| 41% | PATTILUPONE | 11 | "Evita" actress who plays Mona in "Beau Is Afraid" (2 wds.) |
| 41% | TIFFANYHADDISH | 14 | "Keanu" actress who adopted one of the cats that played Keanu in the film: 2 wds. |
| 41% | TOPHERGRACE | 11 | "Predators" actor who played Eric Forman and was cast opposite 18a in "That '70s Show": 2 wds. |
| 41% | NIAVARDALOS | 11 | Actress who plays a bride-to-be in "My Big Fat Greek Wedding" (2 wds.) |
| 41% | ROXIEROKER | 10 | Actress who played Helen Willis, the friendly neighbor in the '70s sitcom "The Jeffersons" which is one of the longest-running sitcoms: 2 wds. |
| 40% | SANDRADEE | 9 | Actress who played Gidget in 1959: 2 wds. |
| 40% | DENISERICHARDS | 14 | Actress who played a Bond Girl in "The World Is Not Enough" and appeared in a guest role in "Two and a Half Men": 2 wds. |
| 40% | KARYNPARSONS | 12 | Actress who played the snobbish cousin of 17-Across in "The Fresh Prince of Bel-Air," which is rumored to be getting a reunion: 2 wds. |
| 40% | DEBRAMESSING | 12 | "Will & Grace" actress who plays Bobbie Costello in "The Alto Knights": 2 wds. |