| 100% | CHANDRAWILSON | 13 | Actress who plays Dr. Miranda Bailey on "Grey's Anatomy" (2 wds.) |
| 80% | SANDRAOH | 8 | Canadian-American actress who played Dr. Cristina Yang on "Grey's Anatomy": 2 wds. |
| 79% | DEBBIEALLEN | 11 | Actress who plays Dr. Catherine Avery on "Grey's Anatomy" (2 wds.) |
| 77% | ELLENPOMPEO | 11 | Actress who plays Dr. Meredith Grey on "Grey's Anatomy" (2 wds.) |
| 61% | LISAEDELSTEIN | 13 | Actress who plays Dr. Cuddy on "House, M.D.": 2 wds. |
| 58% | TORREYDEVITTO | 13 | "Army Wives" actress who plays Dr. Natalie Manning on "Chicago Med": 2 wds. |
| 58% | KATHERINEHEIGL | 14 | "Grey's Anatomy" actress who plays Tully Hart on the Netflix adaptation of 41-Across (2 wds.) |
| 57% | ELLENPOMPEO | 11 | Actress who plays Dr Meredith Grey in US television drama series Grey's Anatomy |
| 56% | ROWANBLANCHARD | 14 | Actress who plays Topanga's daughter Riley on 33-Across: 2 wds. |
| 56% | SALLYSTRUTHERS | 14 | Actress who played Archie's daughter Gloria on 16-Across: 2 wds. |
| 56% | LUCYLIU | 7 | "Kill Bill" actress who plays Dr. Watson in CBS's "Elementary": 2 wds. |
| 56% | LILIREINHART | 12 | Actress who plays Betty on the CW's "Riverdale": 2 wds. |
| 55% | SANDRAOH | 8 | Canadian-born actress who played Dr Cristina Yang in US television series Grey's Anatomy |
| 54% | LORETTASWIT | 11 | Actress who played head nurse Margaret Houlihan on "M*A*S*H": 2 wds. |
| 54% | CHERYLHINES | 11 | Actress who plays the main character's ex-wife on "Curb Your Enthusiasm": 2 wds. |
| 54% | ANTONIATHOMAS | 13 | Actress who plays Shaun's friend and fellow resident Claire on 15-Across: 2 wds. |
| 54% | ANYATAYLORJOY | 13 | Actress who played child prodigy Beth Harmon on "The Queen's Gambit": 2 wds., hyph. |
| 54% | TALITHABATEMAN | 14 | "Annabelle: Creation" actress who plays the astronaut's daughter on "Away": 2 wds. |
| 54% | ODETTEANNABLE | 13 | "Supergirl" actress who plays Geri Broussard on The CW's "Walker": 2 wds. |
| 54% | JUDITHLIGHT | 11 | "Transparent" actress who played Tony's employer Angela on 18-Across: 2 wds. |
| 54% | COBIESMULDERS | 13 | "Stumptown" actress who plays former S.H.I.E.L.D. agent Maria Hill on the Disney+ series "Secret Invasion": 2 wds. |
| 54% | MJRODRIGUEZ | 11 | Actress who plays Blanca on FX's "Pose": 2 wds. |
| 54% | TINALOUISE | 10 | Actress who played Ginger on "Gilligan's Island": 2 wds. |
| 53% | SARA | 4 | First name of Mexican American actress who plays Dr. Callie Torres in Grey's Anatomy |
| 53% | RHEASEEHORN | 11 | Actress who plays Jimmy McGill's love interest, lawyer Kim Wexler, on 33-Across: 2 wds. |
| 53% | MAISIEWILLIAMS | 14 | Actress who played Christian Dior's sister on Apple TV+'s "The New Look": 2 wds. |
| 53% | GEORGIAENGEL | 12 | Actress who played anchorman Ted Baxter's wife on "The Mary Tyler Moore Show": 2 wds. |
| 53% | VALERIEHARPER | 13 | Actress who played Mary's best friend Rhoda on "The Mary Tyler Moore Show": 2 wds. |
| 53% | ROBINTUNNEY | 11 | "The Mentalist" actress who played Sarah Bailey in 1996's "The Craft": 2 wds. |
| 53% | HILARYDUFF | 10 | "Lizzie McGuire" actress who plays Kelsey Peters on TV Land's "Younger": 2 wds. |