| 100% | CHERYLHINES | 11 | Actress who plays the main character's ex-wife on "Curb Your Enthusiasm": 2 wds. |
| 79% | SUSIEESSMAN | 11 | Actress who plays the foul-mouthed wife of the main character's manager Jeff on "Curb Your Enthusiasm": 2 wds. |
| 55% | ISABELSANFORD | 13 | Actress who played Louise Jefferson, the main character on the '70s sitcom "The Jeffersons" which is one of the longest-running sitcoms: 2 wds. |
| 55% | WALTONGOGGINS | 13 | "Justified" actor who plays the main character Wade on 18-Across: 2 wds. |
| 54% | LINDALAVIN | 10 | Actress who played the title character on the sitcom "Alice": 2 wds. |
| 54% | CAMILLERAZAT | 12 | Actress who plays the title character's new friend on 46-Across (2 wds.) |
| 53% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 52% | BARBARABARRIE | 13 | "Breaking Away" actress who played the title character's Nana on 46-Across (2 wds.) |
| 51% | EDIEFALCO | 9 | "The Sopranos" actress who played the title character on "Nurse Jackie": 2 wds. |
| 51% | LILYCOLLINS | 11 | Actress who plays the title character on 46-Across (2 wds.) |
| 51% | SHELLEYLONG | 11 | "Cheers" actress who played Jay's ex-wife DeDe on "Modern Family": 2 wds. |
| 51% | CASSIDYFREEMAN | 14 | "Longmire" actress who plays Jesse's wife Amber on "The Righteous Gemstones": 2 wds. |
| 50% | GEORGIAENGEL | 12 | Actress who played anchorman Ted Baxter's wife on "The Mary Tyler Moore Show": 2 wds. |
| 50% | JANELYNCH | 9 | "Glee" costar who played the main character's mother in the 2022 Broadway revival of 15-Across: 2 wds. |
| 50% | TALITHABATEMAN | 14 | "Annabelle: Creation" actress who plays the astronaut's daughter on "Away": 2 wds. |
| 50% | LILIREINHART | 12 | Actress who plays Betty on the CW's "Riverdale": 2 wds. |
| 49% | ARCHIEPANJABI | 13 | Actress who plays investigator Kalinda Sharma on "The Good Wife": 2 wds. |
| 49% | HOPEDAVIS | 9 | "Wayward Pines" actress who plays the wife of a mob boss on 54-Across (2 wds.) |
| 48% | ODETTEANNABLE | 13 | "Supergirl" actress who plays Geri Broussard on The CW's "Walker": 2 wds. |
| 48% | COBIESMULDERS | 13 | "Stumptown" actress who plays former S.H.I.E.L.D. agent Maria Hill on the Disney+ series "Secret Invasion": 2 wds. |
| 48% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 48% | KENNEDYMCMANN | 13 | Actress who plays the title role on "Nancy Drew": 2 wds. |
| 48% | COURTENEYCOX | 12 | Actress who played the chef Monica Geller on "Friends": 2 wds. |
| 48% | BRIELARSON | 10 | Actress who plays the character of Carol Danvers, a former U.S. Air Force pilot in "Captain Marvel": 2 wds. |
| 48% | FAYEDUNAWAY | 11 | "Network" actress who played the fiancée of Paul Newman's architect character in "The Towering Inferno": 2 wds. |
| 48% | HOPEDAVIS | 9 | "For the People" actress who plays mob wife Gina Baxter on 15-Across: 2 wds. |
| 48% | LOUISAHARLAND | 13 | "Derry Girls" actress who plays the title character on 44-Across (2 wds.) |
| 48% | AYOEDEBIRI | 10 | Actress who plays the chef Sydney Adamu on "The Bear": 2 wds. |
| 48% | LORILOUGHLIN | 12 | Actress who plays Rebecca Donaldson-Katsopolis, Jesse's wife in the 1987 sitcom "Full House": 2 wds. |
| 48% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |