| 100% | BLYTHEDANNER | 12 | Actress who plays Will Truman's mother on "Will & Grace" (2 wds.) |
| 78% | SYDNEYPOLLACK | 13 | Actor who plays Will Truman's father on "Will & Grace" (2 wds.) |
| 78% | GREGORYHINES | 12 | Actor who plays Will Truman's boss on "Will & Grace" (2 wds.) |
| 66% | ERICMCCORMACK | 13 | He played lawyer Will Truman on NBC's "Will & Grace": 2 wds. |
| 65% | JESSICAWALTER | 13 | "Archer" actress who played Michael Bluth's mother Lucille on "Arrested Development": 2 wds. |
| 65% | EMMYROSSUM | 10 | "Shameless" actress who plays Danny's mother on "The Crowded Room": 2 wds. |
| 64% | HEIDIGARDNER | 12 | "Saturday Night Live" actress who plays Jimmy's patient Grace on "Shrinking": 2 wds. |
| 62% | CONSTANCEWU | 11 | Actress who plays 36-Across's mother on "Fresh off the Boat" (2 wds.) |
| 62% | MEGANMULLALLY | 13 | Actress who played a woman who wouldn't sit on George's left on "Seinfeld," but is better known as Karen on "Will & Grace" (2 wds.) |
| 61% | MICHAELONTKEAN | 14 | "Slap Shot" actor who played Sheriff Harry S. Truman on "Twin Peaks": 2 wds. |
| 61% | KELECHIWATSON | 13 | Actress Susan ___, who plays Randall's wife Beth Pearson on "This Is Us": 2 wds. |
| 60% | NAOMIEHARRIS | 12 | Actress who played Chiron's biological mother Paula in "Moonlight": 2 wds. |
| 60% | ROWANBLANCHARD | 14 | Actress who plays Topanga's daughter Riley on 33-Across: 2 wds. |
| 60% | SALLYSTRUTHERS | 14 | Actress who played Archie's daughter Gloria on 16-Across: 2 wds. |
| 60% | SUSANCLARK | 10 | Actress who played the adoptive mother on the 1980s sitcom "Webster": 2 wds. |
| 59% | LAURENGRAHAM | 12 | "Parenthood" actress who played mother Lorelai on 14-Across: 2 wds. |
| 59% | COBIESMULDERS | 13 | "How I Met Your Mother" actress who plays private detective Dex Parios on "Stumptown": 2 wds. |
| 59% | JUNELOCKHART | 12 | Actress of the month who played the mother on "Lassie": 2 wds. |
| 59% | MJRODRIGUEZ | 11 | Actress who plays Blanca on FX's "Pose": 2 wds. |
| 59% | TINALOUISE | 10 | Actress who played Ginger on "Gilligan's Island": 2 wds. |
| 59% | SAMIRAWILEY | 11 | "Orange Is the New Black" actress who plays Moira Strand on "The Handmaid's Tale" (2 wds.) |
| 59% | JUDITHLIGHT | 11 | "Transparent" actress who played Tony's employer Angela on 18-Across: 2 wds. |
| 58% | YARASHAHIDI | 11 | "The Sun Is Also a Star" actress who plays Zoey on the Freeform sitcom "Grown-ish": 2 wds. |
| 58% | CLAIREDANES | 11 | "Homeland" actress who plays Toby Fleishman's ex-wife on "Fleishman Is in Trouble" (2 wds.) |
| 58% | DANIELLEBROOKS | 14 | "Orange Is the New Black" actress who plays Leota Adebayo on "Peacemaker": 2 wds. |
| 58% | LETITIAWRIGHT | 13 | Actress who plays Shuri in the Marvel Cinematic Universe and has been on "Black Mirror": 2 wds. |
| 58% | LAURIEMETCALF | 13 | "The Conners" actress who played Sheldon's mother on "The Big Bang Theory" (2 wds.) |
| 58% | RUBYROSE | 8 | "Orange Is the New Black" actress who plays Kate Kane on 14-Across: 2 wds. |
| 57% | TALITHABATEMAN | 14 | "Annabelle: Creation" actress who plays the astronaut's daughter on "Away": 2 wds. |
| 57% | CONNIENIELSEN | 13 | "Gladiator" actress who plays Diana's mother, Queen Hippolyta: 2 wds. |