| 100% | RENEEZELLWEGER | 14 | Actress who returns to play the title character in "Bridget Jones: Mad About the Boy": 2 wds. |
| 63% | EMMATHOMPSON | 12 | "Howards End" actress who returns as a doctor in "Bridget Jones: Mad About the Boy": 2 wds. |
| 60% | JIMBROADBENT | 12 | "Moulin Rouge!" actor who returns as Bridget's father in "Bridget Jones: Mad About the Boy": 2 wds. |
| 52% | EMILYBLUNT | 10 | "The Girl on the Train" star who plays the title character in "Mary Poppins Returns": 2 wds. |
| 49% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 49% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 48% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 48% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character in Netflix's "Ratched": 2 wds. |
| 47% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 47% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 47% | JULIEANDREWS | 12 | Performer who won an Academy Award for Best Actress for playing the title character in her film debut, "Mary Poppins" (2 wds.) |
| 47% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 46% | ADAMSANDLER | 11 | "Grown Ups" actor who played the title boy's father in "That's My Boy": 2 wds. |
| 46% | ANSELELGORT | 11 | "The Fault in Our Stars" actor who plays the title character in "Baby Driver": 2 wds. |
| 46% | TARONEGERTON | 12 | "Kingsman: The Golden Circle" actor who plays the title character in 16-Across: 2 wds. |
| 46% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |
| 46% | PETERDINKLAGE | 13 | "Game of Thrones" actor who plays the title character in "The Toxic Avenger": 2 wds. |
| 45% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" star who played the title character of 28-Across in a 2015 movie: 2 wds. |
| 45% | SETHMACFARLANE | 14 | "Family Guy" creator who wore a motion-capture suit to portray the title character in "Ted": 2 wds. |
| 45% | RUSSELLCROWE | 12 | "Gladiator" actor who played the title boy's father in "Boy Erased": 2 wds. |
| 45% | SONJASOHN | 9 | "The Wire" actress who plays Nancy, the title boxer's mother, in a 2023 biopic about 40-Across (2 wds.) |
| 45% | STEVECARELL | 11 | "The Big Short" actor who played the title boy's father in "Beautiful Boy": 2 wds. |
| 45% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 45% | EDDIEMURPHY | 11 | "Coming to America" actor who played the title role in 1998's "Dr. Dolittle": 2 wds. |
| 44% | ROBINWILLIAMS | 13 | Actor who played Daniel Hillard, and the title character, in the 1993 film "Mrs. Doubtfire": 2 wds. |
| 44% | LINDALAVIN | 10 | Actress who played the title character on the sitcom "Alice": 2 wds. |
| 44% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 43% | DIANEKEATON | 11 | "Annie Hall" actress who voiced the title character's mother in 18-Across: 2 wds. |
| 43% | KARENGILLAN | 11 | Actress who played Ruby Roundhouse in "Jumanji: Welcome to the Jungle": 2 wds. |
| 43% | OLIVIAMUNN | 10 | "The Predator" actress who plays the title role in "Violet": 2 wds. |