| 100% | DAKOTAJOHNSON | 13 | Actress who will play Anastasia Steele in 18-Across: 2 wds. |
| 65% | JAMIEDORNAN | 11 | Actor who will play Christian Grey in 18-Across: 2 wds. |
| 61% | DAKOTAJOHNSON | 13 | "Presidential" actress who played Anastasia Steele in "Fifty Shades of Grey": 2 wds. |
| 57% | MIAWASIKOWSKA | 13 | Actress who played the daughter of 14- and 32-Across in "The Kids Are All Right": 2 wds. |
| 55% | SHERILYNFENN | 12 | Actress who is known for playing Audrey Horne in the cult TV series "Twin Peaks": 2 wds. |
| 55% | ELLENPOMPEO | 11 | Actress who plays the doctor for whom 18-Across is named (2 wds.) |
| 54% | ALIWONG | 7 | Actress who played Sasha opposite Keanu Reeves in "Always Be My Maybe": 2 wds. |
| 54% | GLENNCLOSE | 10 | "Fatal Attraction" actress who played Iris Gaines, Roy Hobbs's girlfriend, in 18-Across: 2 wds. |
| 53% | JESSICALANGE | 12 | Actress who was nominated for an Emmy for playing 18-Across and for an Oscar for playing 32-Across (2 wds.) |
| 53% | LETITIAWRIGHT | 13 | Actress who plays Shuri in the Marvel Cinematic Universe and has been on "Black Mirror": 2 wds. |
| 53% | KARYNPARSONS | 12 | Actress who played the snobbish cousin of 17-Across in "The Fresh Prince of Bel-Air," which is rumored to be getting a reunion: 2 wds. |
| 53% | LAURAPREPON | 11 | Actress who played Alex Vause, an inmate in the TV series "Orange Is the New Black": 2 wds. |
| 53% | NATASHALYONNE | 13 | Actress who played Nicky Nichols, an inmate in the TV series "Orange Is the New Black": 2 wds. |
| 52% | KATEMULGREW | 11 | Actress who played Galina "Red" Reznikov, an inmate in the TV series "Orange Is the New Black": 2 wds. |
| 52% | KRYSTENRITTER | 13 | "Jessica Jones" actress who plays Lucy in the "Echoes" spin-off of 18-Across: 2 wds. |
| 52% | GRACEKELLY | 10 | Actress who played sheriff Will Kane's wife in "High Noon": 2 wds. |
| 52% | PATTILUPONE | 11 | "Evita" actress who plays Mona in "Beau Is Afraid" (2 wds.) |
| 52% | LEAMICHELE | 10 | Actress who plays 17-Across' girlfriend and was 29-Across' girlfriend in real life: 2 wds. |
| 52% | HAYLEYATWELL | 12 | "Agent Carter" actress who plays 18-Across's wife Evelyn in "Christopher Robin": 2 wds. |
| 51% | JULIAROBERTS | 12 | "August: Osage County" actress who costarred in 18-Across: 2 wds. |
| 51% | REBELWILSON | 11 | "Bridesmaids" actress who played Fat Amy in 14-Across: 2 wds. |
| 51% | JANETLEIGH | 10 | "Psycho" actress who played Rosie DeLeon in 30-Across: 2 wds. |
| 51% | JOSHBROLIN | 10 | Actor who plays the fixer in 18-Across: 2 wds. |
| 51% | JACKIEGLEASON | 13 | Actor who played Minnesota Fats in 18-Across: 2 wds. |
| 51% | MAUDEAPATOW | 11 | "This Is 40" actress who plays 30-Across's sister in "The King of Staten Island": 2 wds. |
| 51% | CHRISSYMETZ | 11 | Actress who plays Kate Pearson in NBC's "This Is Us" (2 wds.) |
| 51% | NICOLACOUGHLAN | 14 | Actress who was born in Galway, Ireland: 2 wds. |
| 50% | BLAKELIVELY | 11 | Actress who wore contact lenses she couldn't see through to play a blind woman in "All I See Is You": 2 wds. |
| 50% | KRISTENBELL | 11 | Actress who is the narrator in "Gossip Girl": 2 wds. |
| 50% | KEELEYHAWES | 11 | "The Missing" actress who plays Dr. Kira Manning in the "Echoes" spin-off of 18-Across: 2 wds. |