| 100% | OPRAH | 5 | Actress Winfrey who plays Mrs. Which in "A Wrinkle in Time" |
| 85% | OPRAHWINFREY | 12 | Actress who plays Mrs. Which in "A Wrinkle in Time" (2 wds.) |
| 76% | OPRAH | 5 | Media mogul who plays Mrs. Which in "A Wrinkle in Time" |
| 75% | MINDYKALING | 11 | Actress who plays Mrs. Who in "A Wrinkle in Time" (2 wds.) |
| 75% | OPRAHWINFREY | 12 | Actress playing Mrs. Which in "A Wrinkle in Time": 2 wds. |
| 61% | OPRAH | 5 | She played Mrs. Which in 2018's "A Wrinkle in Time" |
| 60% | MINDYKALING | 11 | "A Wrinkle in Time" actress who plays Amita in "Ocean's 8" (2 wds.) |
| 59% | MINDYKALING | 11 | "A Wrinkle in Time" actress who plays new writer Molly Patel in "Late Night" (2 wds.) |
| 59% | STORMREID | 9 | "A Wrinkle in Time" actress who plays Jack Radcliff's niece in 35-Across (2 wds.) |
| 58% | STORMREID | 9 | Actress playing Meg Murry in "A Wrinkle in Time": 2 wds. |
| 57% | CORRI | 5 | Adrienne —, actress who played Mrs Alexander in 1971 film drama A Clockwork Orange |
| 57% | MRS | 3 | Title for Whatsit, Who and Which in "A Wrinkle in Time" |
| 54% | MRS | 3 | Title for Who, Which and Whatsit in "A Wrinkle in Time" |
| 54% | PINE | 4 | Actor Chris who plays Mr. Murry in "A Wrinkle in Time" |
| 53% | MARGOTROBBIE | 12 | "Once Upon a Time in Hollywood" actress who plays Kayla Pospisil in "Bombshell" (2 wds.) |
| 53% | ANA | 3 | Actress de Armas who played a CIA agent in "No Time to Die" |
| 53% | KEIRA | 5 | Actress Knightley who played Anna Karenina in a 2012 film |
| 53% | KAHN | 4 | Actress Madeline who plays Mrs. White in "Clue" |
| 52% | KAHN | 4 | Actress Madeline who played Mrs. White in "Clue" |
| 52% | ANNE | 4 | Actress Bancroft who played Mrs. Robinson in "The Graduate" |
| 52% | GALAXYQUEST | 11 | 1999 film in which Sigourney Weaver plays an actress who plays an officer on a spaceship: 2 wds. |
| 52% | OPRAH | 5 | Mrs. Which player in 2018’s “A Wrinkle in Time” |
| 51% | DEBRAMESSING | 12 | Actress who played 17a in the series for which she won a Primetime Emmy Award: 2 wds. |
| 51% | HAWN | 4 | Actress Goldie who plays Mrs. Claus in "The Christmas Chronicles" films |
| 51% | OPRAH | 5 | Actress Winfrey who plays Annie Lee Cooper in "Selma" |
| 51% | CRISTINMILIOTI | 14 | Actress who plays a wedding guest who's stuck in a time loop in 44-Across: 2 wds. |
| 50% | MIMI | 4 | Actress Rogers who plays Mrs. Kensington in the first Austin Powers film |
| 50% | EMMA | 4 | Actress Thompson who plays Mrs. Potts in 2017's "Beauty and the Beast" |
| 50% | DUVERNAY | 8 | Ava who directed Selma and A Wrinkle in Time |
| 49% | EDIE | 4 | Actress Falco who plays a general in "Avatar: The Way of Water" |