| 100% | RAISIN | 6 | Agatha —, fictional creation of M C Beaton who first appeared in a 1992 mystery novel |
| 39% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in 1925 novel The House Without a Key |
| 39% | PERRYMASON | 10 | Lawyer creation of Erle Stanley Gardner who first appeared in 1933 novel The Case of the Velvet Claws |
| 38% | DOCSAVAGE | 9 | Fictional character created by Lester Dent who first appeared in 1933 pulp novel The Man of Bronze |
| 37% | PERRY | 5 | & 25A Lawyer creation of Erle Stanley Gardner who first appeared in 1933 novel The Case of the Velvet Claws |
| 37% | NANCYDREW | 9 | Fictional girl detective who first appeared in 1930 novel The Secret of the Old Clock by Carolyn Keene |
| 36% | DUPIN | 5 | C Auguste —, detective creation of Edgar Allan Poe who first appeared in 1841’s The Murders in the Rue Morgue |
| 36% | DUPIN | 5 | C Auguste —, detective creation of Edgar Allan Poe who first appeared in 1841's The Murders in the Rue Morgue |
| 35% | TWEETYBIRD | 10 | Cartoon canary who first appeared in 1942's A Tale of Two Kitties |
| 35% | HUCKLEBERRY | 11 | ___ Finn, a fictional character who first appeared in 51a and is a friend of the protagonist |
| 35% | CHAN | 4 | Fictional character who first appeared in "The House Without a Key" |
| 34% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in The House Without a Key |
| 33% | CAMPION | 7 | Albert —, detective creation of Margery Allingham who first appeared in 1929 novel The Crime At Black Dudley |
| 33% | TRIXIEBELDEN | 12 | Fictional young female detective who first appeared in a 1948 book by Julie Campbell Tatham: 2 wds. |
| 32% | NANCYDREW | 9 | Fictional young female detective who first appeared in a 1930 book credited to the pen name Carolyn Keene: 2 wds. |
| 31% | HARDYBOYS | 9 | Fictional young male detectives who first appeared in a 1927 book credited to the pen name Franklin W Dixon: 2 wds. |
| 30% | NANCYDREW | 9 | Character who first appeared in "The Secret of the Old Clock" |
| 30% | MYRONBOLITAR | 12 | Fictional basketball player-turned-sports agent who solves mysteries in a series of novels by 35-Across (2 wds.) |
| 29% | GEORGESMILEY | 12 | Fictional spy who first appeared in "Call for the Dead" |
| 29% | POIROT | 6 | Agatha Christie sleuth who first appeared in 1920 |
| 29% | BOBBSEYTWINS | 12 | Fictional young brother-and-sister detectives who first appeared in a 1904 book credited to the pen name Laura Lee Hope: 2 wds. |
| 29% | VANDERVALK | 10 | Piet —, Dutch detective created by Nicholas Freeling who first appeared in 1962 novel Love in Amsterdam |
| 29% | KILGORETROUT | 12 | Fictional novelist who appears in several novels by 41-Across, including "Slaughterhouse-Five" and "Breakfast of Champions" (2 wds.) |
| 28% | TWILIGHT | 8 | First book in a series of vampire novels by Stephenie Meyer |
| 28% | PAULSCHNEIDER | 13 | Actor who played the role of Mark Brendanawicz in "Parks and Recreation", a character that appeared only in the first two seasons: 2 wds. |
| 28% | WONDERWOMAN | 11 | Fictional superhero appearing in comic books who is a founding member of the Justice League and an ambassador of the Amazon people: 2 wds. |
| 28% | JIMMYCARTER | 11 | President who comedically appeared in a 1994 episode of "Home Improvement": 2 wds. |