| 100% | BIS | 3 | Agency of the USDOC whose mission is stopping the proliferation of WMDs, while expanding US exports (abbr.) |
| 35% | ACLU | 4 | Nonprofit organization whose mission is to protect the rights of the people of America: Abbr. |
| 30% | FBI | 3 | Agency whose headquarters is in the J. Edgar Hoover Building: Abbr. |
| 30% | NSO | 3 | Public res. inst., HQed in Boulder, whose mission is to advance understanding of the sun |
| 29% | BEAN | 4 | Alan —, US astronaut who was a member of the Apollo 12 mission |
| 29% | OSC | 3 | Henry Kerner was confirmed by the US Senate in 2017 to be the executive of this agency (abbr.) |
| 28% | SCI | 3 | US org. founded in '73 whose stated mission is to "protect the freedom to hunt and to promote wildlife conservation" (abbr.) |
| 28% | MIT | 3 | The Engineers of the NCAA, whose home games are played near Boston: Abbr. |
| 28% | AMA | 3 | Physician's group whose symbol is the staff of Asclepius: Abbr. |
| 28% | AARP | 4 | US interest group whose mission is "to empower people to choose how they live as they age.": Abbr. |
| 28% | OTISREDDING | 11 | US singer-songwriter whose posthumous album The Dock of the Bay was released in 1968 |
| 28% | AEC | 3 | Former U.S. government agency formed for the development of atomic science and technology: Abbr. |
| 27% | HANCOCK | 7 | John —, US statesman whose signature is the most prominent on the Declaration of Independence |
| 27% | ELK | 3 | — Mountains, range of the Rockies in Colorado, US, whose highest point is Castle Peak |
| 27% | IRS | 3 | Agency that was affected by the Tax Reform Act of 1986: Abbr. |
| 27% | FDR | 3 | Monogram of the president whose face is on the dime |
| 27% | SIXTIMEWINNER | 13 | Unique claim of the U.S. Open player whose name is hidden in 34-Across |
| 27% | SOT | 3 | Org. whose mission is to advance the science and study of the adverse effects of chemical substances on living organisms |
| 27% | TKO | 3 | Boxing term for when a match has to be stopped because one of the fighters is unable to continue: Abbr. |
| 27% | ISR | 3 | U.S. ally whose capital has the letters U-S-A in the middle of its name: Abbr. |
| 26% | OMANI | 5 | Natives of the country whose capital is Muscat |
| 26% | FDR | 3 | Initials of the president whose wife was Eleanor |
| 26% | RONSTADT | 8 | Linda whose "Long, Long Time" is featured in the Last of Us episode of the same name |
| 26% | ALA | 3 | State whose nickname is "the Heart of Dixie": Abbr. |
| 26% | KOREAN | 6 | Official language of the country whose capital is Seoul |
| 26% | YEMENI | 6 | Inhabitant of the country whose capital is Sana'a |
| 26% | EOS | 3 | Goddess whose home was on the edge of Oceanus |
| 26% | MLK | 3 | Initials of the man whose holiday is in mid-January |
| 26% | NASA | 4 | Hit song by Ariana Grande from her 2019 album whose title is named after the U.S. space agency |
| 25% | IRS | 3 | "Taxman" agency of the government: Abbr. |