| 100% | MODERNLOVE | 10 | Amazon anthology series based on a popular "New York Times" column (2 wds.) |
| 48% | DIAGNOSIS | 9 | Documentary web TV series based on The New York Times Magazine column that was released in 2019 |
| 44% | CLARKSTORY | 10 | "The Ron ___," 2006 film starring Matthew Perry based on a real life educator who leaves his hometown to teach in a New York City public school: 2 wds. |
| 43% | TRUEBLOOD | 9 | HBO show based on a series of Charlaine Harris books: 2 wds. |
| 41% | SECRETLEVEL | 11 | Adult animated anthology series on Amazon that's based on 15 different video games: 2 wds. |
| 41% | BRIARPATCH | 10 | Cable anthology series based on a Ross Thomas novel |
| 40% | ALTEREDCARBON | 13 | Netflix series, based on a cyberpunk novel, set more than 300 years in the future: 2 wds. |
| 40% | HANNA | 5 | Amazon Prime series based on a Saoirse Ronan movie |
| 40% | QUEENSUGAR | 10 | OWN series based on a Natalie Baszile novel about a family farm in Louisiana (2 wds.) |
| 39% | SPIRITUNTAMED | 13 | Computer-animated adventure film based on a Netflix TV series (2 wds.) |
| 39% | AMERICANGODS | 12 | Television series based on 45a's novel which is about Shadow Moon, a former convict and Mr. Wednesday, a con artist: 2 wds. |
| 38% | DIRTYJOHN | 9 | Anthology series whose first season on Bravo starred Connie Britton as a woman who falls for a dating scam: 2 wds. |
| 38% | ONEDAYATATIME | 13 | Netflix series based on a 1970s-'80s sitcom (5 wds.) |
| 38% | MODERNLOVE | 10 | Anthology series based off of a relationship column |
| 38% | TWILIGHTZONE | 12 | Anthology film based on a Rod Serling series |
| 37% | CURIOUSGEORGE | 13 | Will Ferrell film based on a story series by H.A. Rey and Margret Rey (2 wds.) |
| 37% | LAFEMMENIKITA | 13 | 1997-2001 USA action/drama series based on a Jean Reno movie: 3 wds. |
| 37% | SLEEPYHOLLOW | 12 | Fox drama based on a Washington Irving story: 2 wds. |
| 36% | SUSANNAKAYSEN | 13 | Author of the 1993 New York Times best seller "Girl, Interrupted": 2 wds. |
| 36% | GILLIANFLYNN | 12 | Author of the 2012 New York Times best seller "Gone Girl": 2 wds. |
| 36% | ELECTRICSLIDE | 13 | 1970s novelty dance based on a Marcia Griffiths song: 2 wds. |
| 36% | HENRYV | 6 | 1989 Emma Thompson movie based on a Shakespeare play: 2 wds. |
| 36% | GAMEOFTHRONES | 13 | Current HBO series based on a series of George R.R. Martin fantasy novels: 3 wds. |
| 36% | NOSIR | 5 | Denial on a military base: 2 wds. |
| 36% | RUDYGIULIANI | 12 | Former New York City mayor who achieved a "Full Ginsburg" by appearing on five different Sunday morning news shows on October 9, 2016: 2 wds. |
| 36% | LESMIZ | 6 | 2012 movie musical based on a Victor Hugo novel, familiarly: 2 wds. |
| 36% | TEENWOLF | 8 | Current MTV drama based on a Michael J. Fox movie: 2 wds. |
| 36% | ATISKETATASKET | 14 | Early hit for 34-Across, based on a nursery rhyme: 2 wds. |
| 36% | ANANT | 5 | "As industrious as ___" (simile based on a hill-dwelling insect): 2 wds. |
| 36% | ONEDAYATATIME | 13 | Netflix series based on a 1970s-1980s sitcom (5 wds.) |