| 100% | QUANTUM | 7 | American science-fiction series, __Leap |
| 71% | GALACTICA | 9 | Battlestar __, popular science fiction series |
| 68% | NOVA | 4 | Science fiction drama series "Terra ___" |
| 66% | STARBASE | 8 | Enterprise headquarters in a science fiction series featuring Spock |
| 65% | THEOUTER | 8 | & 17D US television science fiction series first broadcast in 1963 |
| 64% | KHAN | 4 | 1982 American science fiction film "Star Trek II: The Wrath of ___" |
| 64% | UFO | 3 | 1970s ITV science fiction series created by Gerry and Sylvia Anderson |
| 64% | THINGS | 6 | "Stranger ___," Netflix original science fiction series created by the Duffer Brothers |
| 63% | DENNISETAYLOR | 13 | Former computer programmer who writes the "Bobiverse" science fiction series (3 wds.) |
| 63% | STARTREK | 8 | Long-running science fiction TV series and movies |
| 62% | LENSMAN | 7 | Science fiction book series by Edward Elmer Smith including prequel Triplanetary |
| 61% | SKYWARD | 7 | Science fiction series by 24-Across/40-Across about a fighter pilot on a ruined planet |
| 61% | THETOMORROW | 11 | & 17A 1970s ITV children's science fiction series starring Nicholas Young and Elizabeth Adare |
| 61% | ORPHANBLACK | 11 | Human cloning science fiction series with a 2024 spin-off subtitled "Echoes": 2 wds. |
| 61% | LENSMAN | 7 | Science fiction book series by Edward Elmer Smith including the prequel Triplanetary |
| 59% | EARTH | 5 | "The Day the ___ Stood Still," 2008 American science fiction film starring Jaden Smith and Keanu Reeves |
| 57% | UNREASON | 8 | "The Age of ___" (science fiction series) |
| 56% | SMALLWONDER | 11 | 1985 American science fiction comedy about a small girl who is a robot starring Tiffany Brissette: 2 wds. |
| 56% | BLACKSAILS | 10 | American historical fiction series set as a prequel to Robert Stevenson's "Treasure Island": 2 wds. |
| 54% | DOOMEDPLANET | 12 | The —, tenth and final volume of science fiction novel series Mission Earth by L Ron Hubbard |
| 52% | CARA | 4 | ___ Gee, actress who plays the role of Camina Drummer in the science fiction TV series "The Expanse" |
| 52% | STEVEN | 6 | ___ Strait, actor who plays the role of James Holden in the science fiction TV series "The Expanse" |
| 52% | CAS | 3 | ___ Anvar, actor who plays the role of Alex Kamal in the science fiction TV series "The Expanse" |
| 52% | SHAWN | 5 | ___ Doyle, actor who plays the role of Sadavir Errinwright in the science fiction TV series "The Expanse" |
| 52% | TEKWAR | 6 | Science-fiction novel series created by William Shatner |
| 51% | FRANKIEADAMS | 12 | Actress who plays the role of Bobbie Draper in the science fiction TV series "The Expanse": 2 wds. |
| 51% | BRANDON | 7 | With 40-Across, science fiction and fantasy writer known for the series "Mistborn," "The Reckoners," and 10-Across |
| 50% | HUGO | 4 | Science fiction award |
| 50% | HUGOS | 5 | Science fiction awards |