| 100% | TOXICDOSE | 9 | Amount needed to produce a harmful effect, in medicine |
| 39% | MASH | 4 | Need to make wort, in a brewery |
| 39% | SWORE | 5 | Needed to put money in a jar, perhaps |
| 38% | TWO | 3 | Number needed to tango, in a saying |
| 37% | DOSAGE | 6 | Amount of a medicine to take |
| 37% | PASSMARK | 8 | Score needed to succeed in a test or exam |
| 37% | TMI | 3 | "Not something I needed to know," in a text |
| 37% | VISAS | 5 | They need to be in order at a border |
| 37% | ADVERSELY | 9 | In a harmful way, with damaging effects |
| 36% | OIL | 3 | Liquid that needs to be changed regularly in a car |
| 36% | WHEEL | 5 | There's no need to reinvent it, in a saying |
| 36% | EEL | 3 | 1-Down planted to produce a coconut tree, in Samoan mythology |
| 36% | ICE | 3 | What might need to be scraped off a windshield in winter |
| 36% | GASUP | 5 | Something you don't need to do in a Chevy Volt |
| 35% | AIM | 3 | Talent needed to hit a bull's-eye in darts |
| 35% | ORE | 3 | Resource needed to build a city in the game Catan |
| 35% | POW | 3 | Phrase used to showcase a punch effect in comic books |
| 35% | NEWSHOLE | 8 | Amount of space in a paper to be filled with journalism |
| 35% | ACTIVISTS | 9 | People trying to effect change in a specific area |
| 35% | RESPITE | 7 | Providing relief to those in need of a break |
| 35% | USER | 4 | Person who might need a password to sign in |
| 34% | BRB | 3 | "I need to step away from the conversation for a second," in a text |
| 34% | HOWSOON | 7 | Question in response to "I need this in a hurry" |
| 34% | REED | 4 | Used in 13 Across to produce a tone |
| 34% | ROPE | 4 | What a kid would need in order to play Double Dutch |
| 33% | SPADES | 6 | In ___, term originating through card games that means to have in a great amount |
| 33% | DONOR | 5 | Organ ___ (person who gives a kidney to one in need, for example) |
| 33% | HANDYMAN | 8 | Guy to see "if your broken heart needs repair," in a song |
| 32% | ATMFEE | 6 | Dough needed to produce bread? |
| 32% | TALK | 4 | “We need to ___” (lead-in to a possibly uncomfortable conversation) |