| 100% | SPACEGHOST | 10 | Animated hero who hosted a "Coast to Coast" talk show on 45-Across (2 wds.) |
| 57% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 51% | TAVISSMILEY | 11 | PBS talk show host who formerly had a show on NPR: 2 wds. |
| 49% | JIMMYKIMMEL | 11 | Late-night talk show host who hosts the prime-time game show "Who Wants to Be a Millionaire": 2 wds. |
| 48% | EDSULLIVAN | 10 | Sports/entertainment reporter who hosted a musical variety show from 1948 to 1971: 2 wds. |
| 48% | ROSIEODONNELL | 13 | American TV presenter and activist who has hosted several daytime television talk shows and was a moderator on "The View": 2 wds. |
| 46% | GEORGELOPEZ | 11 | Talk show host who plays a teacher in "Spare Parts": 2 wds. |
| 46% | ELLENDEGENERES | 14 | Daytime talk show host who is a vegan: 2 wds. |
| 45% | RISEANDSHINE | 12 | 43-Across novel about a morning talk show host who is fired because of an on-air gaffe (3 wds.) |
| 45% | KELLIEPICKLER | 13 | Former "American Idol" contestant who's hosting a new daytime talk show with Ben Aaron: 2 wds. |
| 44% | STEPHENCOLBERT | 14 | Host of "The Late Show" who was once a correspondent on "The Daily Show": 2 wds. |
| 44% | JOHNOLIVER | 10 | Host of "Last Week Tonight" who was once a correspondent on "The Daily Show": 2 wds. |
| 44% | MARIEOSMOND | 11 | Singer and talk show host who has been a spokesperson for Nutrisystem: 2 wds. |
| 44% | WENDYWILLIAMS | 13 | TV star who had to take a hiatus from her talk show to address her Graves' disease: 2 wds. |
| 44% | ROSIEODONNELL | 13 | Host of a self-titled talk show who hosted the 1999 and 2000 Grammy ceremonies: 2 wds. |
| 44% | JIMMYKIMMEL | 11 | Talk show host who recently hosted the Oscars for the second year in a row: 2 wds. |
| 42% | CHRISHARRISON | 13 | Host of the game show "Who Wants to Be a Millionaire": 2 wds. |
| 42% | CHELSEA | 7 | With 33-Across, comedian who hosted a late-night talk show on E! from 2007-2014 |
| 41% | ZACHCHERRY | 10 | "The Great American Baking Show" host who plays memory-blocked worker Dylan on 17-Across: 2 wds. |
| 41% | PHILDONAHUE | 11 | Pioneering daytime talk-show host who was a 2024 recipient of the Medal of Freedom: 2 wds. |
| 41% | KELLYCLARKSON | 13 | "American Idol" winner who has hosted a daytime television talk show since 2019 (2 wds.) |
| 41% | ELMO | 4 | Muppet who hosts a talk show on HBO Max |
| 41% | GRAHAMNORTON | 12 | Irish TV presenter (birthday today) who hosts his own British comedy chat show on BBC One: 2 wds. |
| 41% | JENNIFERHUDSON | 14 | "Dreamgirls" star who has hosted a daytime television talk show since 2022 (2 wds.) |
| 41% | DELTABURKE | 10 | Actress (married to 33-Across) who starred on a 1982 soap opera parody also called 18-Across: 2 wds. |
| 41% | DOUGWILSON | 10 | Host of the former TLC series "Moving Up" who's a designer on 31-Across: 2 wds. |
| 40% | MILAKUNIS | 9 | "That '70s Show" actress who voices Meg Griffin on 45-Across (2 wds.) |
| 40% | MRED | 4 | Talking horse on a 1960s TV show: 2 wds. |
| 40% | THEVOICE | 8 | American reality show hosted by Carson Daly, which works in a format similar to 21-Across: 2 wds. |
| 40% | PHILDONAHUE | 11 | Husband of 13-Across who won nine Emmys for hosting his daytime talk show: 2 wds. |