| 100% | SOUTHPARK | 9 | Animated series on Comedy Central: 2 wds. |
| 82% | DRUNKHISTORY | 12 | Educational series on Comedy Central: 2 wds. |
| 70% | SOUTHPARK | 9 | Comedy Central animated series that wrapped its 25th season in 2022: 2 wds. |
| 67% | SOUTHPARK | 9 | Animated Comedy Central series set in a small town in Colorado: 2 wds. |
| 66% | BROADCITY | 9 | Recently ended sitcom on Comedy Central: 2 wds. |
| 57% | JUSTINBIEBER | 12 | 21-year-old pop star who was roasted on Comedy Central on March 30: 2 wds. |
| 55% | BOBSAGET | 8 | "Fuller House" actor who was a roastee on Comedy Central Roast with John Stamos as the roast master: 2 wds. |
| 53% | CHARLIESHEEN | 12 | "Two and a Half Men" actor who was a roastee on Comedy Central Roast with Seth MacFarlane as the roast master: 2 wds. |
| 50% | IAM | 3 | "___ Cait" (documentary series on E!): 2 wds. |
| 50% | THEVENTUREBROS | 14 | Animated series on Adult Swim about two bumbling teen siblings: 3 wds. |
| 49% | SECRETLEVEL | 11 | Adult animated anthology series on Amazon that's based on 15 different video games: 2 wds. |
| 48% | SOUTHPARK | 9 | Emmy-winning animated Comedy Central sitcom created by Trey Parker and Matt Stone: 2 wds. |
| 48% | THEDAILYSHOW | 12 | Comedy Central news satire series that debuted in 1996 (3 wds.) |
| 47% | FAMILYGUY | 9 | Animated series that celebrated its 25th anniversary in 2024: 2 wds. |
| 47% | FAMILYGUY | 9 | Fox animated series created by Seth MacFarlane: 2 wds. |
| 47% | THECUPHEADSHOW | 14 | Adult animated slapstick comedy series on Netflix that's based on a video game: 3 wds. |
| 47% | MAGICCITY | 9 | Mob drama series on Starz, 2012-2013: 2 wds. |
| 47% | ROBOTCHICKEN | 12 | Stop-motion sketch comedy series on Adult Swim featuring a cyborg rooster: 2 wds. |
| 47% | BROADCITY | 9 | Comedy Central sitcom that starred Ilana Glazer and Abbi Jacobson: 2 wds. |
| 47% | YOGIBEAR | 8 | "The ___ Show," animated series set in Jellystone Park: 2 wds. |
| 47% | SOUTHPARK | 9 | Long-running animated series set in the Rockies: 2 wds. |
| 47% | BENSTEIN | 8 | "Win ___'s Money" (former Comedy Central game show): 2 wds. |
| 46% | FAMILYGUY | 9 | Animated series in which Mila Kunis voices a daughter named Meg: 2 wds. |
| 46% | TWINPEAKS | 9 | Series on which Kyle MacLachlan plays FBI Special Agent Dale Cooper: 2 wds. |
| 46% | BOJACKHORSEMAN | 14 | Netflix animated series about a washed-up sitcom star: 2 wds. |
| 45% | FAMILYGUY | 9 | Fox animated series that wrapped its 20th season in 2022: 2 wds. |
| 45% | AMERICANDAD | 11 | TBS animated series that wrapped its 19th season in 2022: 2 wds. |
| 45% | THESIMPSONS | 11 | Fox animated series that wrapped its 33rd season in 2022: 2 wds. |
| 45% | FASHIONPOLICE | 13 | E! reality series on which judges discuss celebrities' clothing choices: 2 wds. |
| 45% | GOODOMENS | 9 | Amazon series on which 31-Across plays the demon Crowley: 2 wds. |