| 100% | THESIMPSONS | 11 | Animated sitcom that featured Homer spilling chocolate on Tom Wolfe's trademark white suit (2 wds.) |
| 32% | BOBSBURGERS | 11 | Animated sitcom that premiered on Fox in 2011 (2 wds.) |
| 31% | THESIMPSONS | 11 | Animated sitcom that debuted with a Christmas episode on December 17, 1989 (2 wds.) |
| 29% | BOBSBURGERS | 11 | Fox animated sitcom that once featured the voice of "Mad Men" star Jon Hamm as a toilet (2 wds.) |
| 28% | THEGOLDENGIRLS | 14 | NBC sitcom that featured Betty White as housemate Rose Nylund (3 wds.) |
| 27% | EDEDDNEDDY | 10 | Animated comedy featuring three preteen boys that's the longest-running original series on 45-Across (4 wds.) |
| 27% | PUNKYBREWSTER | 13 | 2021 Peacock reboot of a 1980s sitcom that featured a grown-up Soleil Moon Frye: 2 wds. |
| 26% | BELOWDECK | 9 | Bravo reality show since 2013 that features crew members on a superyacht: 2 wds. |
| 26% | GUY | 3 | "Family ___," animated sitcom that features a character based on Stephen Hawking |
| 26% | AMERICANDAD | 11 | American adult animated sitcom featuring Roger Smith which is running its 15th season: 2 wds. |
| 26% | THEBEATLES | 10 | Group that featured the bandleader character Sgt. Pepper on its 1967 concept album: 2 wds. |
| 26% | PROJECTRUNWAY | 13 | Lifetime reality series about designing clothes that features on-air mentor Tim Gunn: 2 wds. |
| 26% | THEMOON | 7 | "Over ___," Netflix animated film that features Sandra Oh and John Cho's voices: 2 wds. |
| 25% | BOBS | 4 | "___ Burgers," animated sitcom that featured a Thanksgiving episode |
| 25% | LETME | 5 | "___ Love You," 2016 song by DJ Snake and Justin Bieber that featured on the Billboard Hot 100: 2 wds. |
| 24% | RICKANDMORTY | 12 | Animated sitcom on Adult Swim about a mad scientist's escapades with his grandson: 3 wds. |
| 24% | COUGARTOWN | 10 | 2009-2015 ABC/TBS sitcom that starred "Friends" alum Courteney Cox as a single mom on the dating scene: 2 wds. |
| 24% | THESIMPSONS | 11 | Homer's sitcom: 2 wds. |
| 24% | SEASALT | 7 | White crystals on some chocolate truffles: 2 wds. |
| 24% | GROWINGPAINS | 12 | 1985-1992 sitcom that featured Leonardo DiCaprio in its final season, before he was famous: 2 wds. |
| 24% | THEOFFICE | 9 | NBC workplace sitcom that's a remake of a British TV series: 2 wds. |
| 23% | THEFOGOFWAR | 11 | Documentary film based on Robert S. McNamara that won the Oscar for Best Documentary Feature in 2003: 4 wds. |
| 23% | STARWARS | 8 | 1977 movie that features lightsabers: 2 wds. |
| 23% | THESOPRANOS | 11 | HBO series that featured Edie Falco: 2 wds. |
| 22% | TYKE | 4 | The third WWII homing pigeon (along with White Vision and Winkie) that received the Dickin Medal for gallantry on December 2, 1943 |
| 22% | SEXANDTHECITY | 13 | Former HBO sitcom that airs on E!: 4 wds. |
| 22% | PETERPAN | 8 | 1953 Disney movie that features Tinker Bell: 2 wds. |
| 22% | THECUPHEADSHOW | 14 | Adult animated slapstick comedy series on Netflix that's based on a video game: 3 wds. |
| 22% | DEVILMAYCRY | 11 | Adult animated urban fantasy series on Netflix that's based on a video game: 3 wds. |
| 22% | MADDENNFL | 9 | Video game franchise that featured 15-Across on the cover of the 2011 version: 2 wds. |