| 100% | MEYERS | 6 | Ann ___, first woman to sign with the N.B.A. |
| 56% | ANNMEYERS | 9 | Basketball Hall-of-Famer who was the first woman to sign an N.B.A. contract |
| 52% | DELAWARE | 8 | First Indian tribe to sign a treaty with the U.S. government |
| 51% | ANNMEYERS | 9 | First female to sign with a 103-Down team |
| 49% | RETTON | 6 | First woman to appear on the front of a Wheaties box |
| 48% | ANN | 3 | ___ Compton, first woman to cover the White House for a TV network |
| 48% | UTA | 3 | ___ Pippig, first woman to win the Boston Marathon three times in a row |
| 47% | LESLEYVISSER | 12 | First woman to report from the sidelines for a Super Bowl game (2 wds.) |
| 47% | STEVENASH | 9 | First N.B.A. player to light the Olympic cauldron |
| 47% | NETS | 4 | N.B.A. team that recently agreed to its first trade with the Knicks in over 40 years |
| 47% | DAWN | 4 | ___ Braid, first woman to hold a full-time coaching job in the National Hockey League |
| 47% | FDR | 3 | First prez to appoint a woman to the cabinet |
| 46% | EDITH | 5 | Wharton, the first woman to win a Pulitzer |
| 45% | KAZMATSUI | 9 | First Japanese infielder to sign with a major-league team, familiarly |
| 45% | IDALUPINO | 9 | First woman to direct a film noir (1953's "The Hitch-Hiker") |
| 45% | CURIE | 5 | Surname of the first woman to win a Nobel prize |
| 44% | MARIE | 5 | First name of the first woman to win a Nobel Prize |
| 44% | MIRAINAGASU | 11 | First American woman to land a triple axel at the Olympics |
| 44% | MARIE | 5 | With 33-Across, first woman to win a Nobel Prize |
| 44% | MARIE | 5 | With 7-Across, first woman to win a Nobel Prize |
| 44% | NEE | 3 | Used with the name of a married woman to identify former family |
| 44% | HELEN | 5 | I was the first deaf-blind person to earn a B.A. degree and I campaigned for women's rights |
| 43% | MARIO | 5 | First video game character to be honored with a figure in the Hollywood Wax Museum |
| 43% | ALYSSANAKKEN | 12 | First woman to coach on the field of a Major League Baseball game, for the San Francisco Giants in 2020: 2 wds. |
| 43% | NANCY | 5 | With 90-Down, first woman to lead a major party in Congress |
| 43% | KATIESOWERS | 11 | First woman in the NFL to coach in a Super Bowl, for the San Francisco 49ers in 2020: 2 wds. |
| 43% | EDERLE | 6 | First woman to swim the English Channel |
| 43% | CURIE | 5 | First woman to win the Nobel Prize |
| 43% | AMYMCGRATH | 10 | First woman to fly an F/A-18 in combat for the U.S. Marine Corps |