| 100% | DEL | 3 | Anna ___ Amico, a character played by Maria Bello in "E.R" |
| 47% | SAM | 3 | ___ Taggart, a character played by Linda Cardellini on "E.R" |
| 46% | MISSDAISY | 9 | Character played by Jessica Tandy in a 1989 movie |
| 45% | CAMEO | 5 | Small character played by an A-lister in a film |
| 45% | ELAINEBENES | 11 | Character played by Julia Louis-Dreyfus in a sitcom about "nothing" (2 wds.) |
| 45% | LOLITA | 6 | Character played by Sue Lyon in a 1962 Stanley Kubrick film |
| 44% | GEORGEBAILEY | 12 | Character played by 29-Across in "It's a Wonderful Life" (2 wds.) |
| 44% | COSMOKRAMER | 11 | Character played by Michael Richards in a sitcom about "nothing" (2 wds.) |
| 44% | EMMA | 4 | Jane Austen character played by Anya Taylor-Joy in a 2020 movie |
| 42% | ELAINEBENES | 11 | Character played by Julia Louis-Dreyfus in a sitcom about "nothing" that ended May 14, 1998 (2 wds.) |
| 42% | ANDOR | 5 | Title character played by Diego Luna in a "Star Wars" TV series |
| 42% | MONOLOGUE | 9 | Speech given by one character in a play |
| 42% | DOMINGO | 7 | Womanizing character played by Marcello Hernández in a series of viral Saturday Night Live sketches |
| 41% | DAVIDSTARSKY | 12 | Character played by Ben Stiller in a 2004 comedy-crime film co-starring Owen Wilson as Ken Hutchinson |
| 41% | TONY | 4 | ___ Stark, character played by Robert Downey Jr. in the "Iron Man" film series who sports a distinctive iconic goatee |
| 41% | AMELIE | 6 | Title character played by Audrey Tautou in a quirky 2002 Oscar-nominated French rom-com |
| 40% | BUTCH | 5 | — Cassidy, character played by Paul Newman in a 1969 Western film |
| 40% | GUSTAVOFRING | 12 | Character played by Giancarlo Esposito in "Breaking Bad", who owns Los Pollos Hermanos, besides being a prominent meth distributor: 2 wds. |
| 40% | KHALEESI | 8 | Title for a character played by Emilia Clarke |
| 39% | COSMOKRAMER | 11 | Character played by Michael Richards in "Seinfeld", who is 32-Across's neighbor and is often called a "hipster doofus": 2 wds. |
| 39% | EWING | 5 | J R —, character played by Larry Hagman in US television series Dallas |
| 39% | FURIO | 5 | ___ Giunta, a character played by Federico Castelluccio on "The Sopranos" |
| 39% | SIRPETER | 8 | & 16D 1787 Epsom Derby winner named after a character in R B Sheridan stage play The School for Scandal |
| 39% | ANDI | 4 | Character played by Janelle, in “Glass Onion” |
| 38% | NEO | 3 | Anagram of "one" which is a character played by Keanu Reeves |
| 38% | UMA | 3 | Character played by China Anne McClain in "Descendants 2" |
| 38% | OMAR | 4 | Character played by Michael K. Williams in “The Wire” |
| 38% | NEO | 3 | Character played by 26-Across in 18-Across |
| 38% | JESSEPINKMAN | 12 | Character played by Aaron Paul in "Breaking Bad", who was a crystal meth dealer and worked with the character played by 30-Across: 2 wds. |
| 38% | LEORA | 5 | Character played by Helen Hayes in "Arrowsmith" |