| 100% | LEASALONGA | 10 | As Kim in “Miss Saigon,” she became the first Asian woman to win a Tony |
| 51% | LEA | 3 | ___ Salonga, first Asian woman to win a Tony |
| 49% | JESMYNWARD | 10 | In 2017, she became the first woman to win two National Book Awards for fiction |
| 49% | ITO | 3 | In 1981, she became the first woman to land a triple-triple jump combination in competition |
| 49% | ALTHEAGIBSON | 12 | In 1957, she became the first person of color to win a Wimbledon championship (2 wds.) |
| 49% | WILMA | 5 | Considered the world's fastest woman in the 60s, she became the first American woman to win three golds in a single Olympic Games |
| 46% | SALONGA | 7 | Lea who was the first Asian actress to win a Tony |
| 44% | TONI | 4 | First name of the first Black woman to win a Nobel Prize in Literature |
| 43% | SARAHPALIN | 10 | In 2006, she became the first woman to be elected governor of Alaska: 2 wds. |
| 43% | SUSANAMARTINEZ | 14 | In 2010, she became the first woman to be elected governor of New Mexico: 2 wds. |
| 43% | NIKKIHALEY | 10 | In 2010, she became the first woman to be elected governor of South Carolina: 2 wds. |
| 42% | EILEEN | 6 | ___ Collins, American astronaut who became the first woman to command a space shuttle mission in 1999 |
| 41% | DANICAPATRICK | 13 | Racing great who became the first woman driver to win an Indy car race in April 2008 (2 wds.) |
| 41% | AWKWAFINA | 9 | First Asian-American woman to win a Golden Globe for lead actress in a film |
| 41% | PHYLICIARASHAD | 14 | First Black performer to win a Tony Award for Lead Actress in a Play, for "A Raisin in the Sun" in 2004: 2 wds. |
| 41% | ALISTROKER | 10 | Actress who won a Tony for her role as Ado Annie in the 2019 Broadway revival of "Oklahoma!": 2 wds. |
| 40% | RIDE | 4 | She became the first American woman in space in 1983 |
| 40% | YENTL | 5 | Movie for which Barbra Streisand became the first ever woman to receive a Golden Globe as Best Director |
| 39% | UTA | 3 | ___ Pippig, first woman to win the Boston Marathon three times in a row |
| 39% | MOTHERTERESA | 12 | Albanian-Indian nun who was the first Asian woman (She adopted Indian citizenship) to win the Nobel Peace Prize: 2 wds. |
| 39% | MORRISON | 8 | First Black woman to win the Nobel Prize in Literature |
| 38% | JAMESEARLJONES | 14 | First Black performer to win a Tony Award for Lead Actor in a Play, for "The Great White Hope" in 1969: 3 wds. |
| 38% | RETTON | 6 | First American woman to win the all-around gold in Olympic gymnastics |
| 38% | LEE | 3 | Rebecca ___ Crumpler (first Black woman to become a medical doctor in the US) |
| 37% | FRANCESARNOLD | 13 | First American woman to win the Nobel Prize in Chemistry, in 2018: 2 wds. |
| 37% | PEARLSBUCK | 10 | First American woman to win the Nobel Prize in Literature, in 1938: 3 wds. |
| 37% | CARDIB | 6 | First woman to win a Grammy for Best Rap Album as a solo artist |
| 37% | LIUCIXIN | 8 | Author who, in 2015, became the first Asian to win the Hugo Award for Best Novel, for “The Three-Body Problem” |
| 37% | ANG | 3 | Lee who was the first Asian to win a best-director Oscar |
| 37% | VALENTINA | 9 | ___ Tereshkova, cosmonaut who became the first woman to fly in space in 1964 |