| 100% | GLENN | 5 | Astronaut John who is the oldest person to have flown in space |
| 46% | BETTY | 5 | Actress White who is the oldest person to host "Saturday Night Live" |
| 46% | STEVE | 5 | Fossett, who was the first person to fly around the world alone, in 1995, covering 20,482.26 miles |
| 45% | BETTYWHITE | 10 | "Golden Girls" actress who was the oldest person to host "Saturday Night Live" (2 wds.) |
| 44% | BETTY | 5 | White who is the oldest person ever to host "S.N.L." |
| 44% | JOSEPHRBIDEN | 12 | Former vice president who is the oldest person to be inaugurated as president of the United States (3 wds.) |
| 43% | NEIL | 4 | First name in NASA's prestigious list of astronauts who have been to the moon |
| 43% | ALAN | 4 | Astronaut Shepard who was the first American in space |
| 43% | OCHOA | 5 | Astronaut Ellen who was the first Latina in space |
| 43% | ELLEN | 5 | Astronaut Ochoa who was the first Latina in space |
| 43% | RIDE | 4 | Astronaut Sally who was the first American woman in space |
| 43% | MAE | 3 | Astronaut Jemison who was the first Black woman in space |
| 43% | OCHOA | 5 | Astronaut Ellen who was the first Hispanic woman in space |
| 42% | MAE | 3 | Astronaut Jemison who was the first African-American woman in space |
| 41% | YURI | 4 | Cosmonaut Gagarin who was the first person in space |
| 40% | CURIE | 5 | Marie who is the only person to win a Nobel Prize in two different science fields |
| 40% | ALEKSEI | 7 | Leonov who was the first man to walk in space |
| 40% | YURIGAGARIN | 11 | Russian who was the first person to travel into space and orbit the earth (1961): 2 wds. |
| 40% | ANGELA | 6 | Bassett who was the first person to be nominated for an Oscar for acting in a Marvel movie |
| 40% | MARTHA | 6 | Little ___, rabbit who was the first of her kind to be launched into space in 1959 |
| 39% | DIAMONDJIMBRADY | 15 | Tycoon who was the first person in New York City to own a car |
| 39% | NOBEL | 5 | John B. Goodenough is the oldest person ever to get one (at age 97) |
| 39% | CAMP | 4 | Space ___ (where kids who want to be astronauts might spend the summer) |
| 38% | BRANSON | 7 | Richard who flew to the edge of space in 2021 |
| 38% | SEATTLESLEW | 11 | 1977 Triple Crown winner who was the first American champion to have been undefeated in previous races: 2 wds. |
| 38% | DIAMONDJIMBRADY | 15 | Tycoon who was reputedly the first person in New York City to own an automobile |
| 38% | LAURA | 5 | Actress Dern who was announced to have a role in the next "Star Wars" movie |
| 37% | MADAMSPEAKER | 12 | *Nancy Pelosi was the first person ever to have this title in Congress |
| 37% | CHANGEDMAN | 10 | Whole new person who can literally be found in the answers to starred clues |
| 37% | GLENN | 5 | John who was the first American to orbit the earth |