| 100% | RON | 3 | Astronaut McNair of the "Challenger" tragedy |
| 66% | MCNAIR | 6 | One of the Challenger astronauts |
| 48% | MAE | 3 | Astronaut Jemison of the space shuttle Endeavour |
| 47% | DODGE | 5 | Automaker of the Charger and Challenger |
| 46% | DODGE | 5 | Maker of the Charger and the Challenger |
| 46% | PLANET | 6 | __ of the Apes, Heston is astronaut who crashes |
| 46% | HOBBIT | 6 | Challenger of the dragon Smaug |
| 46% | COMEDY | 6 | The literary opposite of tragedy |
| 45% | SOPHOCLES | 9 | Author of the ancient Greek tragedy "Oedipus Rex" |
| 45% | FANTASTIC | 9 | The "intrepid group of astronauts", __ Four |
| 45% | EMO | 3 | Genre of the song "I Write Sins Not Tragedies" |
| 44% | OTHELLO | 7 | The tragedy of the Moor |
| 43% | HAMLET | 6 | Shakespeare tragedy about the Prince of Denmark |
| 42% | MACBETH | 7 | Shakespeare's tragedy about the king of Scotland |
| 42% | OTHELLO | 7 | Shakespeare tragedy also called the Moor of Venice |
| 42% | RIDDLE | 6 | Legend says the Sphinx asked this of challengers |
| 42% | BASE | 4 | Sea of Tranquillity, for the Apollo 11 astronauts |
| 41% | TANG | 4 | Powdered orange drink that was the beverage of astronauts |
| 41% | CHEM | 4 | One of the subjects that astronaut Story Musgrave has a degree in, for short |
| 40% | CRASH | 5 | 1973 novel about symphorophilia, or the erotic fetishization of tragedies |
| 39% | SOA | 3 | Crime tragedy TV series about the life of Jax Teller: Abbr. |
| 39% | MACBETH | 7 | "The Tragedy of ___" tragedy by Shakespeare about a Scottish general seeking the throne |
| 39% | MOOR | 4 | "The Tragedy of Othello, the ___ of Venice" (full title of a Shakespeare play) |
| 38% | NAN | 3 | "The Tragedy of ___" Masefield play |
| 38% | NEIL | 4 | ___ Armstrong, astronaut who was honored with the Presidential Medal of Freedom in 1969 |
| 37% | THEM | 4 | The challengers |
| 37% | MAEJEMISON | 10 | The first Black female astronaut and winner of a National Achievement Scholarship in 1973: 2 wds. |
| 37% | COEN | 4 | "The Tragedy of Macbeth" director Joel |
| 37% | COEN | 4 | “The Tragedy of Macbeth” director Joel |
| 37% | NAN | 3 | Masefield's "The Tragedy of _____" |