| 100% | RAYMOND | 7 | Autistic savant played by Dustin Hoffman in 15-Across |
| 56% | BABBITT | 7 | Raymond, played by Dustin Hoffman in Rain Man |
| 52% | MAN | 3 | "Rain ___," 1988 American comedy drama film starring Dustin Hoffman and Tom Cruise in which Hoffman plays an autistic savant |
| 50% | RAINMAN | 7 | Dustin Hoffman plays a savant in this drama |
| 44% | MUMBLES | 7 | Dick Tracy villain played by Dustin Hoffman |
| 44% | BERNSTEIN | 9 | Carl __, reporter played by Dustin Hoffman on film |
| 43% | LITT | 4 | Played by Rick Hoffman in Suits, Lewis |
| 42% | HARRYCALLAHAN | 13 | Police inspector played by 15-Across in "Sudden Impact": 2 wds. |
| 41% | LENNYBRUCE | 10 | Real-life comic played in film by Dustin Hoffman |
| 40% | JOHNNYENGLISH | 13 | Inept British spy played by 15-Across who "Strikes Again" in 2018 (2 wds.) |
| 40% | DAEMON | 6 | Prince played by 15-Across in the HBO fantasy series "House of the Dragon" |
| 40% | NEWTSCAMANDER | 13 | Character played by 15-Across in "Fantastic Beasts and Where to Find Them": 2 wds. |
| 40% | BLACKJACK | 9 | Card game played by Tom Cruise and Dustin Hoffman in "Rainman" |
| 39% | ANITA | 5 | Bernardo's girlfriend in 15-Across (played by Rita Moreno) |
| 39% | RAINMAN | 7 | 1988 film in which Dustin Hoffman plays the autistic heir to a fortune: 2 wds. |
| 39% | SARAHCONNOR | 11 | Action hero played by 48-Across in a film series that began with 15-Across (2 wds.) |
| 39% | PHILIP | 6 | Prince played by 15-Across in the first two seasons of the Netflix historical drama "The Crown" |
| 39% | MARIA | 5 | "I Feel Pretty" singer in 15-Across (played by Natalie Wood) |
| 38% | ANTONCHEKHOV | 12 | Russian writer who created the characters played by 15-Across, 40-Across, and 45-Across in "The Seagull" |
| 38% | JAKEPERALTA | 11 | Fictional detective played by 20-Across in 15-Across/41-Across (2 wds.) |
| 37% | ELIZABETH | 9 | Queen played by 15-Across in "Shakespeare in Love," a role for which she won a Best Supporting Actress Oscar |
| 36% | RAINMAN | 7 | Film in which actor Hoffman plays an autistic genius |
| 35% | GLORIASTEINEM | 13 | Feminist journalist played by 15-Across and Alicia Vikander in a 2020 biopic based on the memoir "My Life on the Road" (2 wds.) |
| 34% | NEO | 3 | Character played by 26-Across in 18-Across |
| 34% | LENNY | 5 | Comedian played by Dustin |
| 34% | TOLEDO | 6 | City in 15 Across |
| 34% | BBALL | 5 | Game played by the 15-Across, for short (Hyph.) |
| 33% | AMES | 4 | College city in 15 Across |
| 33% | BATWOMAN | 8 | The CW superhero played by 15-Across and 29-Across |
| 33% | VINCENTVANGOGH | 14 | Painter played by 46-Across in 19-Across: 3 wds. |