| 100% | ROCKMEBA | 8 | B.B. King's first Top 40 hit |
| 67% | BORNTORUN | 9 | Springsteen's first Top 40 hit |
| 67% | PIANOMAN | 8 | Billy Joel's first Top 40 hit |
| 67% | UPONCRPLECREEK | 14 | The Band's first Top 40 hit |
| 66% | AMIE | 4 | Pure Prairie League's first Top 40 hit |
| 66% | SPANISHHARLEM | 13 | Ben E. King's first Top 10 hit |
| 60% | EATIT | 5 | First Top 40 hit for "Weird Al" |
| 60% | EATIT | 5 | First Top 40 hit for Weird Al Yankovic |
| 55% | STILLINTOYOU | 12 | 2013 single that was Paramore's first Top 10 hit on the "Billboard" Mainstream Top 40 chart (3 wds.) |
| 54% | LABAMBA | 7 | Top 40 hit whose first two words translate to "to dance" |
| 53% | CHERRYCHERRY | 12 | Neil Diamond's first top-40 hit, with a repetitive title: 2 wds. |
| 52% | BORDERLINE | 10 | Madonna's first top 10 hit |
| 51% | FRANKIEVALLI | 12 | *Lead singer of a group whose first two Top 40 hits reached #1 |
| 50% | EVIL | 4 | "___ Ways" (Santana's first Top 10 hit song) |
| 49% | ABOO | 4 | "Bug ___" (1999 Destiny's Child Top 40 hit) (2 wds.) |
| 49% | WHATYOUNEED | 11 | INXS's first top 10 hit, from 1986: 3 wds. |
| 48% | BEG | 3 | "Ain't 2 Proud 2 ___" (first Top 40 hit for TLC) |
| 45% | OHS | 3 | "Ex's & __": Top 10 hit for Elle King |
| 45% | RAPPERSDELIGHT | 14 | First hip-hop single to enter Billboard's Top 40 chart |
| 44% | BEVERLYHILLS | 12 | Single from the album "Make Believe" that was 42-Across's first Top 10 hit (2 wds.) |
| 44% | LABAMBA | 7 | 1959 Spanish-language Top 40 hit |
| 44% | OTIS | 4 | Redding with 11 Top 40 hits |
| 44% | COLE | 4 | Natalie with 12 Top 40 hits |
| 43% | SULTANS | 7 | First top 10 hit for Dire Straits: __ of Swing |
| 43% | COVERBAND | 9 | Group playing Top 40 hits, e.g. |
| 43% | RAITT | 5 | Bonnie with five 1990s Top 40 hits |
| 43% | EATIT | 5 | Weird Al's first Top-40 song |
| 43% | THETHRILLISGONE | 15 | 1970 B. B. King hit |
| 43% | BETTER | 6 | 2018 song that was 17-Across's first solo top 10 hit |
| 42% | TRES | 4 | "___ Hombres," first Top 40 album by ZZ Top |