| 100% | PARAMORE | 8 | Band that played its song “Misery Business” in 2022 for the first time since retiring it four years earlier |
| 42% | VINYLS | 6 | Records that outsold CDs in 2022, for the first time in 35 years |
| 41% | USPOSTAGE | 9 | It fell in 2016 for the first time since 1919 |
| 40% | VINYL | 5 | Medium that outsold CDs in 2020 for the first time since the 1980s |
| 38% | RADIO | 5 | It was used to play music for the first time in 1906 |
| 35% | ACHES | 5 | Some things to complain about after you've just played flag football for the first time in nine years |
| 35% | BEATLES | 7 | The ___, English rock band that released the song "What's the New Mary Jane" 28 years after it was first recorded |
| 35% | LPS | 3 | In 2020, they outsold CDs for the first time since 1986 |
| 34% | DEANMARTIN | 10 | His 1959 song "Let It Snow! Let It Snow! Let It Snow!" hit the top 10 for the first time ever in 2021: 2 wds. |
| 34% | BEAT | 4 | "___ It," song from 14a that won the Grammy for Record of the Year in 1984 |
| 33% | LEAVE | 5 | "___ the Door Open," song by Silk Sonic that won the Grammy Award for Song of the Year in 2022 |
| 33% | NOAH | 4 | Most popular boy's name in 2013, demoting Jacob for the first time since 1999 |
| 33% | POI | 3 | Food that tourists in Hawaii often try for the first time |
| 33% | BARBIE | 6 | Doll that ran for president for the first time in 1992 |
| 32% | TETRIS | 6 | Video game “beaten” for the first time, in 2023, by thirteen-year-old Willis Gibson, who advanced so far that the screen froze |
| 32% | TIGERSLAM | 9 | Winning four consecutive majors over a two-year span, as named for the first to do it |
| 32% | SQUID | 5 | Colossal ___, marine animal filmed in its natural habitat for the first time in 2025 |
| 31% | JAMESBOND | 9 | British spy played by 33-Across for the first time in 48-Across (2 wds.) |
| 31% | MARINEONE | 9 | Presidential carrier that flew with an all-women crew for the first time in 2009 |
| 31% | DRWHO | 5 | BBC classic whose title role will be played by a woman for the first time in 2017 |
| 31% | JOSEFELICIANO | 13 | His 1970 song "Feliz Navidad" hit the top 10 for the first time ever in 2020: 2 wds. |
| 30% | DIDNT | 5 | "___ We Almost Have It All," number-one hit by Whitney Houston that received a Grammy nomination for Song of the Year in 1988 |
| 30% | LONDON | 6 | "___ Calling," song by British punk rock band the Clash which has the name of a city in its title that is known for the clock tower"Big Ben" |
| 30% | INC | 3 | Business magazine that, in 1981, was the first to feature Steve Jobs on its cover |
| 30% | MIAS | 4 | Lucien —, captain of the France rugby union team that won the Five Nations outright for the first time in 1959 |
| 30% | KIDS | 4 | New ___ on the Block, boy band that debuted in 1984 and which is known for the song "Step by Step" |
| 30% | PREMIERES | 9 | Plays for the first time |
| 30% | LOB | 3 | Tennis shot that buys some time for the person who hit it |
| 30% | BCNR | 4 | For the First Time band, familiarly |
| 30% | REO | 3 | 1976 rock album, or the first word of the band that made it |