| 100% | MILHOUSE | 8 | Bart's best friend in The Simpsons |
| 64% | PAULIE | 6 | Rocky's best friend in the "Rocky" films |
| 64% | FLOUNDER | 8 | Fish, Ariel's best friend in The Little Mermaid |
| 63% | BARNEY | 6 | Fred's best friend in the animated sitcom "The Flintstones" |
| 63% | NED | 3 | Peter Parker's best friend in the "Spider-Man" franchise |
| 62% | NED | 3 | Leeds who is Spider-Man's best friend in the MCU movies |
| 61% | SAMWISE | 7 | Frodo's best friend in Lord of the Rings |
| 60% | CHANDLER | 8 | Joey's best friend in the sitcom "F.R.I.E.N.D.S" |
| 60% | SHIRLEY | 7 | Laverne's best friend in the 1970s sitcom starring Penny Marshall and Cindy Williams |
| 59% | CAL | 3 | Ricky's best friend in Talladega Nights: The Ballad of Ricky Bobby |
| 58% | DAVE | 4 | ___ Coulier, who played Joey Gladstone, Jesse and Danny's best friend in the 1987 sitcom "Full House" |
| 58% | ANDREABARBER | 12 | Actress who played Kimmy Gibbler, D.J's best friend in the 1987 sitcom "Full House:" 2 wds. |
| 57% | NALA | 4 | Simba's best friend in "The Lion King" |
| 57% | MIA | 3 | Lucia's best friend in "The White Lotus" |
| 57% | MILHOUSE | 8 | Bart Simpson's best friend |
| 55% | BART | 4 | Milhouse's best friend, on "The Simpsons" |
| 54% | STAR | 4 | Patrick ___, SpongeBob's best friend and neighbor in the animated TV series, "SpongeBob SquarePants" |
| 54% | BOOTS | 5 | Dora's furry monkey best friend in the animated children's TV series, "Dora the Explorer" |
| 53% | WOODY | 5 | Buzz Lightyear's best friend in "Toy Story" who features in the song "You've Got a Friend in Me" |
| 53% | CARL | 4 | Lenny's best friend on "The Simpsons" |
| 51% | BANGER | 6 | Groupie best friends reunite in The __ Sisters |
| 51% | MELANIE | 7 | Scarlett's sister-in-law and best friend in "Gone With the Wind" |
| 50% | SETH | 4 | Evan's best friend in "Superbad" |
| 50% | FRENCHY | 7 | Sandy's best friend in Grease |
| 50% | KENICKIE | 8 | Danny's best friend in Grease |
| 50% | DONKEY | 6 | Shrek's best friend in "Shrek" |
| 50% | ARE | 3 | "Diamonds ___ a Girl's Best Friend," song that Kylie Minogue performed at the opening ceremony of Fox Studios in Sydney |
| 50% | ETHEL | 5 | Lucy's best friend in old TV |
| 50% | GERALD | 6 | Arnold's best friend in "Hey Arnold!" |
| 50% | LISA | 4 | Bart's sister, in "The Simpsons" |