| 100% | RATHBONE | 8 | Basil who played Sherlock Holmes |
| 70% | JONNYLEEMILLER | 14 | Actor who played Sherlock Holmes on "Elementary": 3 wds. |
| 67% | CUMBERBATCH | 11 | "Doctor Strange" actor Benedict, who plays Sherlock Holmes in BBC's "Sherlock" |
| 65% | WILLFERRELL | 11 | "Anchorman" actor who plays Sherlock Holmes in the upcoming movie "Holmes & Watson": 2 wds. |
| 64% | COOK | 4 | Peter ___, actor who played Sherlock Holmes in the 1978 British film "The Hound of the Baskervilles" |
| 63% | RATHBONE | 8 | Basil __ played Sherlock Holmes in the 30s/40s |
| 63% | NIGEL | 5 | Bruce who played Watson in Sherlock Holmes films |
| 61% | OWEN | 4 | Actor Reginald, who played both Dr. Watson and Sherlock Holmes |
| 59% | MCADAMS | 7 | Rachel —, actress who played Irene Adler in 2009 action film Sherlock Holmes |
| 59% | NIGEL | 5 | Actor Bruce who played Watson in "The New Adventures of Sherlock Holmes" |
| 56% | IRENE | 5 | ___ Adler, iconic character from the Sherlock Holmes stories who was played by Lara Pulver on screen |
| 55% | BRETT | 5 | Jeremy —, actor who played the title role in 1980s ITV drama series The Adventures of Sherlock Holmes |
| 55% | ZUCCO | 5 | George —, Manchester-born actor who played Professor Moriarty in 1939 film drama The Adventures of Sherlock Holmes |
| 55% | RAPACE | 6 | Noomi —, actress who played Madam Simza Heron in 2011 adventure film Sherlock Holmes: A Game of Shadows |
| 55% | MARY | 4 | ___ Morstan, Watson's wife in the Sherlock Holmes stories who was played by Amanda Abbington on screen |
| 55% | LAW | 3 | Actor Jude, who played Watson on "Sherlock Holmes" |
| 54% | STEPHENS | 8 | Robert —, actor who played the title role in 1970 comedy-adventure film The Private Life of Sherlock Holmes |
| 54% | RAPACE | 6 | Noomi —, Swedish actress who played Madam Simza Heron in 2011 adventure film Sherlock Holmes: A Game of Shadows |
| 52% | IRENE | 5 | Adler who outwitted Sherlock Holmes |
| 52% | ADLER | 5 | Irene who outwitted Sherlock Holmes |
| 51% | JUDELAW | 7 | "Alfie" actor who played Dr. Watson in the movie "Sherlock Holmes": 2 wds. |
| 51% | JUDELAW | 7 | Actor who plays John Watson in the 2009 film "Sherlock Holmes" (2 wds.) |
| 49% | JUDELAW | 7 | Actor who plays 22-Across/41-Across in the 2009 film "Sherlock Holmes" (2 wds.) |
| 48% | KATIE | 5 | Holmes who played Jackie Kennedy |
| 48% | IAN | 3 | Actor McKellen who plays Holmes in "Mr. Holmes" |
| 47% | IRENE | 5 | Adler who called Sherlock Holmes "formidable" |
| 46% | VIOLIN | 6 | Instrument played by Sherlock Holmes |
| 44% | SHERLOCK | 8 | Detective Holmes who's played by Benedict Cumberbatch |