| 100% | BANE | 4 | Batman's enemy who is credited to be the only villain to have "broken the bat" |
| 42% | VALKILMER | 9 | Is the only blonde actor to have played Batman: 2 wrds. |
| 41% | SAHL | 4 | Satirist who said "If you were the only person left on the planet, I would have to attack you. That's my job" |
| 41% | SAHL | 4 | Political satirist who said "If you were the only person left on the planet, I would have to attack you. That's my job" |
| 40% | MBA | 3 | CFO's degree, maybe (Bush is the only president to have one) |
| 39% | DOMEE | 5 | Shi who was the first woman to have the sole director’s credit on a Pixar feature, for “Turning Red” |
| 39% | ZEE | 3 | Arizona is the only state to have one |
| 38% | BOJACKSON | 9 | American athlete who has also acted in minor roles, and is the only one to have been named "All-Star" in both football and baseball: 2 wds. |
| 38% | SAMUELCHASE | 11 | Founding father who is the only Supreme Court justice to have ever been impeached |
| 38% | IGGYAZALEA | 10 | "Fancy" singer who is one of only two music acts to have their first two hit singles rank #1 and #2 simultaneously on the U.S. "Billboard" Hot 100 chart (2 wds.) |
| 38% | PATENT | 6 | Lincoln is the only U.S. president to have one |
| 38% | PHD | 3 | Woodrow Wilson is the only U.S. president to have one |
| 38% | PHD | 3 | Woodrow Wilson was the only U.S. prez to have one |
| 38% | PHD | 3 | Woodrow Wilson was the only U.S. president to have one |
| 36% | SHANE | 5 | Classic western hero who says "A man has to be what he is, Joey. Can't break the mold" |
| 36% | KOBEBRYANT | 10 | LA Lakers legend fondly remembered as "Black Mamba" who is the only player in NBA history to have two jersey numbers retired by the same team: 2 wds. |
| 36% | ELI | 3 | ___ Broad, American entrepreneur and philanthropist, who is the only individual to have created two Fortune 500 companies in different industries |
| 36% | MIKAELA | 7 | ___ Shiffrin, American alpine skier who is the only athlete to have won all six FIS Alpine Ski World Cup disciplines |
| 36% | PATRICKROY | 10 | Former Montreal Canadiens goaltender who has 551 wins and is the only player in NHL history to win the Conn Smythe trophy thrice: 2 wds. |
| 36% | FDR | 3 | President who said "The only thing we have to fear is fear itself": Abbr. |
| 35% | FASTRELIEF | 10 | The only thing we have to fear is ... feeling better quickly? |
| 35% | SHAKESPEARE | 11 | Whom the first use of the nine long adjectives is credited to |
| 34% | MARCEAU | 7 | Mime Marcel who is the only actor to speak in Mel Brooks's "Silent Movie" |
| 34% | MARX | 4 | Philosopher who wrote, “The philosophers have only interpreted the world, in various ways. The point, however, is to change it” |
| 34% | SONTAG | 6 | Susan who wrote, "The writer's first job is not to have opinions but to tell the truth" |
| 34% | DST | 3 | What Ariz. and Hawaii are the only two states not to have |
| 34% | GEHRIG | 6 | Yankee who was the first major-leaguer to have his number retired |
| 34% | MARCOPOLO | 9 | Venetian explorer, who is known to be the first to have detailed accounts of travel to, and about China: 2 wds. |
| 34% | ANAISNIN | 8 | Who wrote "The only abnormality is the incapacity to love" |
| 34% | DITTO | 5 | The White House's Jessica, who in 2018 was found to have violated the Hatch Act with political tweets |