| 100% | ADAMWEST | 8 | Batman actor from the 1960s who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 68% | STEVEWOZNIAK | 12 | Co-founder of Apple and noted philanthropist who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 68% | ELONMUSK | 8 | CEO of SpaceX and product architect of Tesla who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 51% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who guest stars as himself on "The Big Bang Theory" (2 wds.) |
| 51% | WIL | 3 | Actor Wheaton who made several guest appearances on "The Big Bang Theory" |
| 50% | WIL | 3 | Actor Wheaton who has guest appearances on "The Big Bang Theory" |
| 50% | JUDDHIRSCH | 10 | "Superior Donuts" actor who guest stars as Leonard's dad on "The Big Bang Theory" (2 wds.) |
| 50% | WIL | 3 | "Star Trek: TNG" actor Wheaton who made several guest appearances on "The Big Bang Theory" |
| 46% | JIMPARSONS | 10 | Actor who plays Sheldon on "The Big Bang Theory" (2 wds.) |
| 46% | JOHNNYGALECKI | 13 | Actor who plays Leonard on "The Big Bang Theory" (2 wds.) |
| 45% | WIL | 3 | Actor Wheaton who had a recurring role on "The Big Bang Theory" |
| 45% | BRADPITT | 8 | Actor from "Mr. & Mrs. Smith," who made a guest appearance on then-spouse Jennifer Aniston's "Friends": 2 wds. |
| 45% | LAURIEMETCALF | 13 | "Lady Bird" actress who guest stars as Sheldon's mom on "The Big Bang Theory" (2 wds.) |
| 44% | MAYIMBIALIK | 11 | "The Big Bang Theory" actress who earned a doctorate in neuroscience from 33-Down: 2 wds. |
| 43% | DEAN | 4 | "Breaking Bad" actor Norris who had a recurring role on "The Big Bang Theory" |
| 43% | WIL | 3 | Actor Wheaton who occasionally guest-stars on "The Big Bang Theory" |
| 43% | WIL | 3 | Actor Wheaton who's guest-starred on "The Big Bang Theory" |
| 42% | JIMPARSONS | 10 | "The Big Bang Theory" actor who played Michael in "The Boys in the Band": 2 wds. |
| 41% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 41% | LAURIEMETCALF | 13 | "The Conners" actress who played Sheldon's mother on "The Big Bang Theory" (2 wds.) |
| 40% | KALEYCUOCO | 10 | Actress who plays Penny on "The Big Bang Theory" (2 wds.) |
| 40% | KATEYSAGAL | 10 | "Sons of Anarchy" actress who played Penny's mother on "The Big Bang Theory" (2 wds.) |
| 40% | MAYIMBIALIK | 11 | Actress who played young C.C. Bloom in the 1988 film "Beaches" and Amy Farrah Fowler on "The Big Bang Theory" in 2019: 2 wds. |
| 40% | WIL | 3 | Wheaton with guest appearances on "The Big Bang Theory" |
| 39% | HELENHUNT | 9 | "As Good as It Gets" actress, who made a guest appearance on then-spouse Hank Azaria's "The Simpson": 2 wds. |
| 39% | BRADLEYCOOPER | 13 | Actor who had a song from "A Star Is Born" chart on the Billboard Hot 100 in 2018: 2 wds. |
| 39% | CHUCKLORRE | 10 | Creator of "Two and a Half Men" and "The Big Bang Theory," who is also the co-creator of CBS's new show "Young Sheldon": 2 wds. |
| 38% | WIL | 3 | Actor Wheaton with a recurring role on "The Big Bang Theory" |
| 38% | JIMPARSONS | 10 | "The Big Bang Theory" actor who narrates 44-Across (2 wds.) |
| 38% | LEVAR | 5 | ___ Burton, "Star Trek" actor who appeared on a "Sheldon Cooper Presents: Fun with Flags" segment in "The Big Bang Theory" |